Issue 30, 2012

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone§

Abstract

The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.

Graphical abstract: Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

Supplementary files

Article information

Article type
Communication
Submitted
20 2 2012
Accepted
19 3 2012
First published
20 3 2012

Org. Biomol. Chem., 2012,10, 5811-5814

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

L. Cao, J. P. Maciejewski, S. Elzner, D. Amantini and P. Wipf, Org. Biomol. Chem., 2012, 10, 5811 DOI: 10.1039/C2OB25353D

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