DOI: 10.1039/A900458K
(Paper)
Reference Section for: Chem. Commun., 1999, 657-658
Investigation of restricted backbone conformations as an explanation for the exceptional thermal stabilities of duplexes involving LNA (Locked Nucleic Acid):† synthesis and evaluation of abasic LNA
(Note: The full text of this document is currently only available in the PDF Version )
Lisbet Kværnø and Jesper Wengel
Abstract
In order to investigate the structural basis of the unique hybridization properties of LNA (Locked Nucleic Acid), an abasic LNA monomer (a 1-deoxy-2-O,4-C-methylene-D-ribofuranose derivative) was synthesized and evaluated with respect to influence on duplex stability, showing that effects mediated via the nucleobase are pivotal for the properties of LNA.
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