The biomimetic oxidation of dieldrin using polyhalogenated metalloporphyrins

Abstract

Biomimetic oxidation of dieldrin produces the same metabolites as generated in vivo, which suggest a ‘radical oxygen- rebound’ mechanism.

References

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8. The cooxidant (0.66 mmol) was added with stirring, at room temperature, in ten equal portions every 30 min to a solution of the porphyrin catalyst (0.032 mmol) in 10 ml of solvent (A, B, or C). An hour after the last addition of cooxidant the mixture was poured onto water (50 ml) and CH₂Cl₂(50 ml). After separation the aqueous phase was extracted with CH₂Cl₂(2 × 20 ml). The combined organic phases were dried over MgSO₄, filtered and concentrated to 1 ml which was applied to a thick layer silica TLC plate and developed with light petroleum–EtOAc (5∶1).
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