The H2O-promoted controllable synthesis of diverse 3-carboxyl and 3-acyl substituted tetrahydroquinolines and 3,4-dihydroquinolin-2(1H)-ones from readily available feedstocks was developed by a hydride transfer strategy.
Metal-free synthesis of medicinally important carbamoylated dihydroquinolinones using readily available, cheap and environment-friendly materials with good to excellent yields.
An electrochemical dehalogenative carbo-cyclization of alkyne- and nitrile-tethered α-halocarbonyls has been developed to access 3,4-dihydroquinolin-2-ones and quinoline-2,4-diones. The reaction also occurs with alkene-tethered derivatives.
In this review, we summarize and discuss recent achievements in palladium-catalyzed carbonylative reactions of activated alkyl halides. Aliphatic carboxylic acid derivates were prepared effectively with various nucleophiles.
This paper demonstrates tandem trifluoromethylation/C(sp2)–H annulation using Langlois’ reagent as the CF3 source for the electrochemical synthesis of functionalized tetrahydroquinolines and dihydroquinolinones.