Issue 6, 2016

In situ iodination and X-ray crystal structure of a foldamer helix bundle

Abstract

We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods. We suggest that this simple method may be of use to those engaged in structural foldamer research as a potential solution to the phase problem.

Graphical abstract: In situ iodination and X-ray crystal structure of a foldamer helix bundle

Supplementary files

Article information

Article type
Communication
Submitted
21 set 2015
Accepted
10 nov 2015
First published
12 nov 2015

Chem. Commun., 2016,52, 1202-1205

In situ iodination and X-ray crystal structure of a foldamer helix bundle

G. W. Collie, K. Pulka-Ziach and G. Guichard, Chem. Commun., 2016, 52, 1202 DOI: 10.1039/C5CC07916K

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