Palladium-catalysed regioselective hydroamination of 1,3-dienes: synthesis of allylic amines

Abstract

Catalytic hydroamination of unactivated 1,3-dienes represents a sustainable and atom-economic C–N bond forming process. Here, we present a novel catalytic system consisting of Pd(cod)Cl₂ in combination with DPEphos for the selective 1,4-hydroamination (anti-Markovnikov reaction) of a series of acyclic and cyclic dienes. The reactions proceed in good yields and allow for the exclusive formation of allylic amines with high regioselectivity and do not need any additives.