Aldoximes Enable Proton-Relayed NMR Hyperpolarisation

Abstract

NMR signals can be greatly enhanced, or hyperpolarised, by interactions with para-hydrogen. We demonstrate here that oximes can be reversibly hyperpolarised by coordination to an iridium complex, that oxime E/Z geometry is significant for activity, and that hyperpolarised oximes can subsequently transfer these enhanced signals through proton exchange.