Issue 24, 2023

Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

Abstract

This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.

Graphical abstract: Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

Article information

Article type
Paper
Submitted
06 ago 2023
Accepted
16 nov 2023
First published
17 nov 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 7077-7085

Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

M. J. Hernández-Esparza, I. Fratoddi, S. Cerra, K. Juarez-Moreno and R. Huirache-Acuña, Nanoscale Adv., 2023, 5, 7077 DOI: 10.1039/D3NA00605K

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