Issue 7, 2015

Polymeric biomaterials for the delivery of platinum-based anticancer drugs

Abstract

Since cisplatin, cis-diamminedichloroplatinum(II), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overcome these limitations, various drug-delivery systems have been developed based on diverse organic and inorganic materials. In particular, the versatility of polymeric materials facilitates the tuning of drug-delivery systems to meet their primary goals. This review focuses on the progress made over the last five years in the application of polymeric nanoparticles for the delivery of platinum-based anticancer drugs. The present article not only describes the fundamental principles underlying the implementation of polymeric nanomaterials in platinum-based drug delivery, but also summarizes concepts and strategies employed in the development of drug-delivery systems.

Graphical abstract: Polymeric biomaterials for the delivery of platinum-based anticancer drugs

Article information

Article type
Review Article
Submitted
04 feb 2015
Accepted
05 apr 2015
First published
20 apr 2015
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2015,3, 1002-1017

Polymeric biomaterials for the delivery of platinum-based anticancer drugs

J. Kim, S. Pramanick, D. Lee, H. Park and W. J. Kim, Biomater. Sci., 2015, 3, 1002 DOI: 10.1039/C5BM00039D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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