Issue 99, 2023

Photochemical reductive deamination of alpha-amino aryl alkyl ketones

Abstract

Photochemical reductive deamination of alpha-amino aryl alkyl ketones under photosensitizer-free conditions is presented. This protocol features high efficiency and selectivity. A plausible reaction pathway is proposed based on ultraviolet–visible absorption investigation, control experiments and deuterium-labelling studies. Mechanistic study reveals that the alpha-hydrogen atom of the ketone product originated from water.

Graphical abstract: Photochemical reductive deamination of alpha-amino aryl alkyl ketones

Supplementary files

Article information

Article type
Communication
Submitted
29 set 2023
Accepted
15 nov 2023
First published
16 nov 2023

Chem. Commun., 2023,59, 14685-14688

Photochemical reductive deamination of alpha-amino aryl alkyl ketones

J. Liang, Y. Su and Y. Zou, Chem. Commun., 2023, 59, 14685 DOI: 10.1039/D3CC04837C

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