Issue 30, 2012

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone§

Abstract

The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.

Graphical abstract: Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

Supplementary files

Article information

Article type
Communication
Submitted
20 feb 2012
Accepted
19 mar 2012
First published
20 mar 2012

Org. Biomol. Chem., 2012,10, 5811-5814

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

L. Cao, J. P. Maciejewski, S. Elzner, D. Amantini and P. Wipf, Org. Biomol. Chem., 2012, 10, 5811 DOI: 10.1039/C2OB25353D

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