A novel, metal-free reductive intramolecular ANRORC-type rearrangement was developed for synthesis of structurally diverse 2-(benzimidazol-2-yl)quinolin-4(1H)-ones and their analogues from 3-(2-(2-nitrophenyl)-2-oxoethyl)quinoxalin-2(1H)-ones.
A novel ANRORC type rearrangement/intermolecular cyclocondensation cascade of 5,6-dicyano-3-(2-oxo-2-ethyl)pyrazin-2(1H)-ones with hydrazine hydrate is disclosed, providing an efficient strategy synthesizing 2-(pyrazol-3-yl)imidazo[4,5-d]pyridazines.
Herein, a NaOH-promoted isomerization of pirazolopyrimidines to pyrazolopyridines, arising via an ANRORC mechanism studied using DFT, and the products' synthetic and photophysical utility are provided.
A trifluoromethyl group substituted C–C bonded nitrogen-rich energetic material nitro pyrazole-oxadiazole (4), its salts (5–6) and nitro pyrazole-triazole (7) were synthesized and their energetic properties were thoroughly investigated.
Skeletal editing enables atom-level modifications to molecular skeletons. This review highlights advances in single-atom insertions, deletions, and transmutations in (hetero)cyclic systems, offering a comprehensive view on cutting-edge strategies.