This review highlights the advances from the past decade that provide readers with essential tools for designing and implementing radical sulfonylation using SO2 surrogates in organic synthesis.
A photocatalyst-free route to quinazolinones using rongalite as a C1 synthon was developed via in situ O2˙− generation, confirmed by EPR analysis. The method offers broad scope, gram-scale synthesis, and N-formylation.
A mild, solvent-controlled Rongalite reduction converts 3,3-dichlorooxindoles into either 3-chloro-2-oxindoles or 2-oxindoles. This inexpensive, metal-free protocol offers simple operation, short reaction times and high yields.
A facile organophosphine-mediated skeletal reorganization of benzo[c][1,2]dithiol-3-ones is developed to forge 2,3-dihydrobenzothiazin-4-ones and benzo[d][1,3]oxathiin-4-ones by using rongalite as a C1 synthon.
A rongalite-mediated triple functionalization of N-allyl bromodifluoroacetamides with electron-rich heteroarenes via a sulfonylation/ethylation/heteroarylation sequence to prepare multifunctional lactam-substituted alkyl sulfones is presented.