This review highlights the advances from the past decade that provide readers with essential tools for designing and implementing radical sulfonylation using SO2 surrogates in organic synthesis.
A photocatalyst-free route to quinazolinones using rongalite as a C1 synthon was developed via in situ O2˙− generation, confirmed by EPR analysis. The method offers broad scope, gram-scale synthesis, and N-formylation.
A mild, solvent-controlled Rongalite reduction converts 3,3-dichlorooxindoles into either 3-chloro-2-oxindoles or 2-oxindoles. This inexpensive, metal-free protocol offers simple operation, short reaction times and high yields.
A mild, metal- and hydride-free protocol employing inexpensive rongalite in water enables efficient and scalable synthesis of α-hydroxymethyl ketones with excellent chemoselectivity and broad functional group tolerance.
In this manuscript, an efficient leaving group-activated methylene alcohol strategy for the preparation of primary propargyl alcohols from terminal alkynes by employing the bulk industrial product rongalite as the C1 unit has been described.