A HOTf-catalyzed dehydrative alkylation of 3-hydroxyisoindolinones with unactivated ketones was developed, which provided a quick route for the synthesis of C3-alkyl 3,3-disubstituted isoindolinones.
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
A new annulation of 3-aryl-3-hydroxyisoindolinones for the efficient synthesis of isoindolinone-derived spiroisochromenes is reported.
In this work, we report a method for the synthesis of functionalized hydroxyisoindolines under visible light stimulation with synergistic interactions of eosin Y, nBu4NBr and oxygen.
An organocatalyzed asymmetric synthesis of Csp2–N atropisomers by formal Csp2–O amination has been established from 3-alkynyl-3-hydroxyisoindolinones and 1-methylnaphthalen-2-ols.