Recent advances in synthetic strategies of isoxazoles and their role in medicinal chemistry.
Lone pair electrons dominate the binding of isoxazole derivatives to metal oxide surfaces, while aromatic groups show reduced affinity, revealing a fundamental shift from metal to metal oxide surface interactions.
The study summarizes the findings from the last eight years of research on heterocyclic core-based epidermal growth factor receptor inhibitors. This provides an invaluable tool for oncology drug discovery.
This review summarizes the latest trends and developments of isoxazole-enabled alkyne amination reactions and their applications in divergent heterocycle synthesis.
The work describes a practical approach for the one-pot access of 4-aryl- or glycosyl NH-1,2,3-triazoles from a multicomponent reaction involving aldehydes, nitroalkanes, and NaN3 in the presence of 5 mol% of SMA as a biocompatible catalyst.