Polyfunctional thiionized-, selenolized-, and alkylated 5-alkylidene 3-pyrrolin-2-one derivatives are easily constructed via a metal-free regioselective oxidative annulation reaction.
The chiral phosphoric acid-catalyzed asymmetric de novo construction of 4-pyrrolin-2-ones has been accomplished via an intermolecular (3+2) reaction of azoalkenes with azlactones.
A visible-light-driven diversity-oriented synthesis of α-ketoester β-enamino esters, 3,3-difluoro-4-pyrrolin-2-ones, and 3-fluoro-3-pyrrolin-2-ones employing bromodifluoroacetates and β-enamino esters has been developed.
Here, we describe the one-pot assembly of imidazo[1,2-a]pyridine and quinoxaline heterocyclic cores by the electrophilic tandem cyclization between 3,5-diaryl substituted 5-hydroxy-3-pyrrolin-2-ones and the corresponding nitrogen bis-nucleophiles.
This feature article focuses on the synthesis and applications of vinyl sulfoxonium ylides under metal-mediated and metal-free conditions.