The metal-free C–H functionalisation is providing environmentally benign, cost-effective, sustainable catalytic systems. Comprehensive developments of various metal-free C–H functionalisation reactions are the focal point of this review.
This research article highlights PIFA's versatility in organic synthesis, emphasizing its role in enabling diverse reactions and promoting its eco-friendly attributes over heavy transition metals.
Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
The recent advances in the construction of N–N bond from primary and secondary amines via direct oxidation method, is an interest of both academia and industry for preparing the organic frameworks such as azos, hydrazines, indazoles and triazoles.
A room-temperature PIFA-mediated oxidative cyclization enables rapid synthesis of benzo[4,5]thiazolo[3,2-a]indoles. The method is broad in scope (28 examples) and enables late-stage diversification and access to bioactive scaffolds.