The recent advances in the construction of N–N bond from primary and secondary amines via direct oxidation method, is an interest of both academia and industry for preparing the organic frameworks such as azos, hydrazines, indazoles and triazoles.
Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
This work discloses a new methodology for the site-selective direct installation of a nitro group at the benzene ring of 2H-indazoles with excellent selectivity towards the synthesis of 7-nitroindazole derivatives.
Herein, we report a t-BuONa-promoted method for the site-selective silylation of 2H-indazoles.
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.