Herein, we report the rhodium-catalyzed tunable divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated benzofurans via C−H alkenylation/DG migration and [3 + 2] annulation, respectively.
The dihydrobenzofuran scaffolds demonstrate a wide range of biological activities. Several transition metals have been employed as catalysts for the efficacious synthesis of these structurally important frameworks.
This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications in the construction of structurally diverse and biologically valuable spirocyclic scaffolds.
A rhodium-catalyzed carboamination of olefin with the retention of double bond has been demonstrated. A deacylative carboamination of the maleimide has been achieved. In addition to carboamination, we have also disclosed ortho C–H olefination of phenoxyacetamides.
Recent progress on catalytic nitrene transfer reactions with hydroxylamine derivatives as prevalent precursors is summarized in this highlight.