This review highlights the roles of nitriles in covalent inhibitors, their reactivity, examples of pharmaceuticals containing the cyano group and recent developments of nitrile-based inhibitors.
This review summarizes the recent advances and applications of fluorescent probes into which natural products are incorporated. We hope this review to provide insights on the probe design, synthesis and its applications.
The present work demonstrates the design and synthesis of new indolo–pyrazole derivatives, their cytotoxic evaluation, tubulin polymerization inhibition, and molecular modeling studies.
Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry.
Deconstruction of a bicyclic tetrahydroquinoline-6-carboxylic acid scaffold into aminosalicylic acids yielded dual MCL-1/BCL-xL inhibitors from an MCL-1 selective lead.