Systematic screening of excipients to stabilize aerosolized lipid nanoparticles for enhanced mRNA delivery

Brittany J. Heiser, Mae M. Lewis, Meysam Mohammadi Zerankeshi, Emily K. Netemeyer, Ashlee M. Hernandez, Alexander E. Marras and Debadyuti Ghosh

RSC Pharm., 2025
DOI: 10.1039/D5PM00061K

The rise of mRNA therapeutic vaccines

Jinlu Du, Ziling Fan, Jiangming Huang, Zhengyuan Li, Hongguo Hu and Yanxia Li

RSC Pharm., 2025, 2, 235
DOI: 10.1039/D4PM00309H

Lipid Nanoparticles for mRNA Delivery in Cancer Immunotherapy

Yasir Alshehry, Xiang Liu, Wenhua Li, Qiyan Wang, Janét Cole and Guizhi Zhu

AAPS J, 2025, 27
DOI: 10.1208/s12248-025-01051-8

Influence of ionisable lipid and sterol variations on lipid nanoparticle properties and performance

Caitlin McMillan, Amy Druschitz, Stephen Rumbelow, Ankita Borah, Rebecca Macfarlane, Zahra Rattray and Yvonne Perrie

Journal of Controlled Release, 2025, 386, 114056
DOI: 10.1016/j.jconrel.2025.114056

Reducing Complexity in Lipid Nanoparticles: Three-Component Zwitterionic Amino Lipids for Targeted Extrahepatic mRNA Delivery

Joshua J. Robinson, Di Zhang, Pratima Basak, Amogh Vaidya, Sumanta Chatterjee, Xiaoyan Bian, Minjeong Kim, Xizhen Lian, Yehui Sun, Erick Guerrero, Xu Wang, Sang M. Lee, Shuai Liu, Junyu Gong, Mayank Tiwari, Godwin K. Babanyinah, Mihaela C. Stefan, Lukas Farbiak and Daniel J. Siegwart

ACS Biomater. Sci. Eng., 2025, 11, 4853
DOI: 10.1021/acsbiomaterials.5c00631

Exploring the Challenges of Lipid Nanoparticle Development: The In Vitro–In Vivo Correlation Gap

Sarah Lindsay, Muattaz Hussain, Burcu Binici and Yvonne Perrie

Vaccines, 2025, 13, 339
DOI: 10.3390/vaccines13040339

Unlocking the potential of microfluidic assisted formulation of exenatide-loaded solid lipid nanoparticles

Büşra Arpaç Birro, Cristiano Pesce, Francesco Tognetti, Agnese Fragassi, Lisa Casagrande, Mariangela Garofalo, Stefano Salmaso and Paolo Caliceti

International Journal of Pharmaceutics, 2025, 678, 125686
DOI: 10.1016/j.ijpharm.2025.125686

Structure and Morphology of Lipid Nanoparticles for Nucleic Acid Drug Delivery: A Review

Aniket Udepurkar, Cedric Devos, Peter Sagmeister, Francesco Destro, Pavan Inguva, Soroush Ahmadi, Etienne Boulais, Yufeng Quan, Richard D. Braatz and Allan S. Myerson

ACS Nano, 2025, 19, 21206
DOI: 10.1021/acsnano.4c18274

From in vitro to in vivo: The Dominant role of PEG-Lipids in LNP performance

Ankita Borah, Valeria Giacobbo, Burcu Binici, Ranald Baillie and Yvonne Perrie

European Journal of Pharmaceutics and Biopharmaceutics, 2025, 212, 114726
DOI: 10.1016/j.ejpb.2025.114726

Exploring the impact of commonly used ionizable and pegylated lipids on mRNA-LNPs: A combined in vitro and preclinical perspective

Burcu Binici, Zahra Rattray, Assaf Zinger and Yvonne Perrie

Journal of Controlled Release, 2025, 377, 162
DOI: 10.1016/j.jconrel.2024.11.010

Mind the Age Gap: Expanding the Age Window for mRNA Vaccine Testing in Mice

Muattaz Hussain, Agata Ferguson-Ugorenko, Rebecca Macfarlane, Natalie Orr, Samuel Clarke, Michael J. A. Wilkinson, Linda Horan and Yvonne Perrie

Vaccines, 2025, 13, 370
DOI: 10.3390/vaccines13040370

Low-Cost Microfluidic Mixers: Are They up to the Task?

Jade Forrester, Callum G. Davidson, May Blair, Lynn Donlon, Daragh M. McLoughlin, Chukwuebuka R. Obiora, Heather Stockdale, Ben Thomas, Martina Nutman, Sarah Brockbank, Zahra Rattray and Yvonne Perrie

Pharmaceutics, 2025, 17, 566
DOI: 10.3390/pharmaceutics17050566