Microneedles: multifunctional devices for drug delivery, body fluid extraction, and bio-sensing

Zhitao Wang, Siyu Tong, Jiaqi Niu, Cheng Cao, Ang Gao, Yingao Jiao, Yanfei Fu, Dongxia Li, Xinni Pan, Daxiang Cui, Nengquan Sheng, Li Yan, Shengsheng Cui, Shujing Lin and Yanlei Liu

Nanoscale, 2025, 17, 740
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Quantitative evaluation of accelerated transdermal drug delivery by electroosmosis via frustoconical porous microneedles

Soichiro Tottori, Sae Ichinose, Fumika Sakai, Reiji Segawa, Taiki Yokoyama, Gaobo Wang and Matsuhiko Nishizawa

J. Mater. Chem. B, 2025, 13, 5023
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Wearable Microneedle-Based Array Patches for Continuous Electrochemical Monitoring and Drug Delivery: Toward a Closed-Loop System for Methotrexate Treatment

Marc Parrilla, Usanee Detamornrat, Juan Domínguez-Robles, Sensu Tunca, Ryan F. Donnelly and Karolien De Wael

ACS Sens., 2023, 8, 4161
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Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery

Gaobo Wang, Natsuho Moriyama, Soichiro Tottori and Matsuhiko Nishizawa

Materials Today Bio, 2025, 31, 101504
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Recent Advances in Wearable Healthcare Devices: From Material to Application

Xiao Luo, Handong Tan and Weijia Wen

Bioengineering, 2024, 11, 358
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Bilaterally Aligned Electroosmotic Flow Generated by Porous Microneedle Device for Dual‐Mode Delivery

Gaobo Wang, Kosuke Kato, Sae Ichinose, Daisuke Inoue, Airi Kobayashi, Hitoshi Terui, Soichiro Tottori, Makoto Kanzaki and Matsuhiko Nishizawa

Adv Healthcare Materials, 2024, 13
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Individually-addressable composite microneedle electrode array by mold-and-place method for glucose detection

Jeongmin Kim, Hyemin Kim, SeungHyun Park, Seung Yeop Han, Hyeonaug Hong, Da Som Yang, Yong Jae Kim, JiYong Lee, Jaeho Kim, Seung-Woo Cho and WonHyoung Ryu

Sensors and Actuators B: Chemical, 2024, 401, 134884
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Review of Microneedle Technology for Targeted Therapeutics in Vitiligo: Design Principles, Application Prospects

Yihui Yu, Wei Li, Qian Li, Wenyan Liu, Sanquan Zhang, Xibao Zhang and Jingyao Liang

DDDT, 2024, Volume 18, 4901
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Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives

Yao Li, Qiu Chen, Tingting Wang, Zengkai Ji, Sagar Regmi, Haibin Tong, Jian Ju and Aifang Wang

J Nanobiotechnol, 2025, 23
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Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive monitoring of MDMA in interstitial fluid

Ana-Maria Drăgan, Marc Parrilla, Sofie Cambré, Juan Domínguez-Robles, Usanee Detamornrat, Ryan F. Donnelly, Radu Oprean, Cecilia Cristea and Karolien De Wael

Microchemical Journal, 2023, 193, 109257
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An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect

Xiaoyi Mo, Keyu Meng, Zehui Li, Shanwei Lan, Zhengda Ren, Xihong Fu, Chenglin Li, Tiancheng Sun, Denghui Xie, Zhongmin Zhang and Hui‐Jiuan Chen

Small Methods, 2025, 9
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Advancements in microneedle technology: current status and next-generation innovations

Siddhant Kumar and Rahul Shukla

Journal of Microencapsulation, 2024, 41, 782
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Strategies to develop polymeric microneedles for controlled drug release

Bo Zhi Chen, Yu Ting He, Ze Qiang Zhao, Yun Hao Feng, Ling Liang, Juan Peng, Chen Yu Yang, Hiroshi Uyama, Mohammad-Ali Shahbazi and Xin Dong Guo

Advanced Drug Delivery Reviews, 2023, 203, 115109
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Modelling Hollow Microneedle-Mediated Drug Delivery in Skin Considering Drug Binding

Tanmoy Bhuimali, Sarifuddin, Diganta Bhusan Das and Prashanta Kumar Mandal

Pharmaceutics, 2025, 17, 105
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Multidimensional Delivery Strategies for Liposomal Transdermal Drug Delivery Systems

Chengyun Wang, Yanhui Wang, Xinyue Lan, Longjiao Zhu, Jiaxuan Gu, Weichen Hou, Baiqiang Zhai, Dantong Li, Hongtao Tian and Wentao Xu

ACS Materials Lett., 2025, 7, 1795
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3D printed hollow microneedles: the latest innovation in drug delivery

Mahmood Razzaghi and Mohsen Akbari

Expert Opinion on Drug Delivery, 2025, 1
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Ultrathin and Breathable Silk-Protein Electronic Tattoos for Iontophoretic Transdermal Drug Delivery

Shalik Ram Joshi, Hyunji Lee, Soohoon Lee, Juwan Choi and Sunghwan Kim

ACS Appl. Polym. Mater., 2025, 7, 4457
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TSA-SAB co-loaded liposome self-dissolving microneedle synergistic delivery system: a breakthrough dual-drug loading strategy for multi-target therapy of hypertrophic scars

Lu-Lu Cheng, Jia-Hui Yu, Bi-Jin Yao, Ying-Ping Li, Rui-Xiang Peng, Jing-Hang Xu and Jun Shi

Pharmaceutical Development and Technology, 2025, 1
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Wearable 3D-printed solid microneedle voltammetric sensors based on nanostructured gold for uric acid monitoring

Marc Parrilla, Nathalie Claes, Celia Toyos-Rodríguez, Caroline E.M.K. Dricot, Annemarijn Steijlen, Sarah Lebeer, Sara Bals and Karolien De Wael

Biosensors and Bioelectronics, 2025, 289, 117934
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A smart lab on a wearable microneedle patch with convolutional neural network‐enhanced colorimetry for early warning of syndrome of inappropriate antidiuretic hormone secretion

Yuanting Xie, Kaidi Li, Jing Liu, Ying Zhou, Chuangjie Zhang, Yan Yu, Jianlong Wang, Lei Su and Xueji Zhang

Aggregate, 2025, 6
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3D Printed Hollow Microneedles for Dermal and Transdermal Drug Delivery: Design, Fabrication, Application, and Perspective

Amirreza Ghaznavi, Sonia Alavi, Yang Lin, Seth A. Hara, Richard A. Gemeinhart and Jie Xu

Mol. Pharmaceutics, 2025, 22, 2747
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Advancements in minimally invasive transdermal drug delivery systems

Preeti Prasad, Amit Upadhyay, Sonali Jayronia, Shivansh Pathak, Ashutosh Tiwari and Sudhanshu Mishra

Letters in Drug Design & Discovery, 2025, 22, 100045
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Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

Jieun Han, Yi‐Jeong Choi and Seung‐Kyun Kang

Adv Healthcare Materials, 2024, 13
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Fabrication and mechanical modelling of dissolvable PVA/PVP composite microneedles with biocompatibility for efficient transdermal delivery of ibuprofen

Min Xiao, Zifeng Wang, Yanru An, Yingqi Dai, Xinghao Wang and Zhigang Zhu

Journal of Biomaterials Science, Polymer Edition, 2024, 35, 1439
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Wearable platform based on 3D-printed solid microneedle potentiometric pH sensor for plant monitoring

Marc Parrilla, Annemarijn Steijlen, Robbe Kerremans, Joe Jacobs, Louise den Haan, Janne De Vreese, Yorben Van Noten Géron, Phil Clerx, Regan Watts and Karolien De Wael

Chemical Engineering Journal, 2024, 500, 157254
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An electrochromism-equipped enzymatic biofuel cell system combined with hollow microneedle array for self-powered glucose sensing in interstitial fluid

Nan Xiao, Haotian Li, Zheyuan Fan, Fangfang Luo, Dingxi Lu, Wen Sun, Zhanhong Li, Zifeng Wang, Yutong Han and Zhigang Zhu

Microchim Acta, 2025, 192
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Conductive electronic skin coupled with iontophoresis for sensitive skin treatment

Dan Song, Wei Tao, Zhuo Tang and Xuefeng Hu

Journal of Drug Delivery Science and Technology, 2024, 95, 105650
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Morphology design of polymer microneedle arrays: Key factors from the application perspective

Baoling Jia, Tiandong Xia, Xiaohui Wang, Yangtao Xu and Zhenyu Guo

Journal of Drug Delivery Science and Technology, 2023, 88, 104883
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Remote‐Controlled Sensing and Drug Delivery via 3D‐Printed Hollow Microneedles

Mahmood Razzaghi, Joel Alexander Ninan, Mostafa Azimzadeh, Esfandyar Askari, Alireza Hassani Najafabadi, Ali Khademhosseini and Mohsen Akbari

Adv Healthcare Materials, 2024
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Perspective: Materials and Electronics Gaps in Transdermal Drug Delivery Patches

Camryn H. Payne and Trisha L. Andrew

ECS Sens. Plus, 2024, 3, 047001
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Dynamics of insertion and extraction of hollow pyramidal microneedles: experiments and numerical modelling

Rahul Nadda, Diganta Bhusan Das, Tahir Emre Yalcin, Abraham M. Abraham, Eneko Larrañeta and Ryan F. Donnelly

International Journal of Pharmaceutics, 2025, 682, 125989
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Recent advances in dissolving microneedle delivery systems for breast cancer therapy

Jingqi Sun, Yutong Zhao, Zicong Xu, Xiao-Ling Xu and Jin Su

Expert Opinion on Drug Delivery, 2025, 1
DOI: 10.1080/17425247.2025.2547016

Microneedle-based nanodrugs for tumor immunotherapy

Tianye Wang, Hongyu Liu, Meng Li, Zao Ji, Xinyuan Zhang, Nan Wang, Ying Chen, Jin Sun and Funan Liu

Journal of Controlled Release, 2025, 380, 539
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Integrated therapeutic strategies for various cutaneous malignancies: Advances and challenges of multifunctional microneedle patches toward clinical translation

Yan-Yan Hu, Qiang Jin, Ji Wang, Su-Fan Wu, Yong He and Pei-Hong Jin

Chemical Engineering Journal, 2024, 494, 153033
DOI: 10.1016/j.cej.2024.153033

Recent progress of microneedles in transdermal immunotherapy: A review

Xinyi Ai, Jiayi Yang, Zhenda Liu, Teng Guo and Nianping Feng

International Journal of Pharmaceutics, 2024, 662, 124481
DOI: 10.1016/j.ijpharm.2024.124481

Future directions: what LIES ahead for smart biochemical wearables in health monitoring?

S. Kharb

Front. Anal. Sci., 2025, 4
DOI: 10.3389/frans.2024.1509815