Mass spectrometry imaging methods for visualizing tumor heterogeneity

Kyle D Duncan, Helena Pětrošová, Julian J Lum and David R Goodlett

Current Opinion in Biotechnology, 2024, 86, 103068
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Untargeted Spatial Metabolomics and Spatial Proteomics on the Same Tissue Section

Gregory W. Vandergrift, Marija Veličković, Le Z. Day, Brittney L. Gorman, Sarah M. Williams, Bindesh Shrestha and Christopher R. Anderton

Anal. Chem., 2025, 97, 392
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Factorial-Design-Based Optimization of a Commercial MALDI-2 timsTOF Mass Spectrometer for Lipid Analysis

Seth W. Croslow, Chen H. Sirois and Jonathan V. Sweedler

J. Am. Soc. Mass Spectrom., 2025, 36, 942
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Optimized MALDI2-Mass Spectrometry Imaging for Stable Isotope Tracing of Tissue-Specific Metabolic Pathways in Mice

Yanyan Chen, Yuanyuan Song, Zhu Yang, Yi Ru, Peisi Xie, Jing Han, Xuyang Chai, Jianing Wang and Zongwei Cai

Anal. Chem., 2025, 97, 499
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SagMSI: A graph convolutional network framework for precise spatial segmentation in mass spectrometry imaging

Mudassir Shah, Linlin Wang, Lei Guo, Chengyi Xie, Thomas Ka-Yam Lam, Lingli Deng, Xiangnan Xu, Jingjing Xu, Jiyang Dong and Zongwei Cai

Analytica Chimica Acta, 2025, 1358, 344098
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Systematic method optimisation approach for small molecule imaging on the SELECT SERIES MALDI MRT - Drug mapping in fingerprints, a case study

Rohith Krishna, James Langridge, Emmanuelle Claude, Robert Bradshaw, Laura Cole and Simona Francese

Analytica Chimica Acta, 2025, 1354, 343998
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Spatially resolved metabolomics: From metabolite mapping to function visualising

Xinyue Min, Yiran Zhao, Meng Yu, Wenchao Zhang, Xinyi Jiang, Kaijing Guo, Xiangyi Wang, Jianpeng Huang, Tong Li, Lixin Sun and Jiuming He

Clinical & Translational Med, 2024, 14
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Experimental and Computational Evaluation of Lipidomic In-Source Fragmentation as a Result of Postionization with Matrix-Assisted Laser Desorption/Ionization

Gregory W. Vandergrift, William Kew, Amity Andersen, Jessica K. Lukowski, Young Ah Goo and Christopher R. Anderton

Anal. Chem., 2024, 96, 16127
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Enhanced visualization of endocannabinoids spatial distribution in mouse brain via MALDI-2 mass spectrometry imaging

Emanuela Salviati, Francesca Guida, Danila La Gioia, Fabrizio Merciai, Sabatino Maione, Vincenzo Di Marzo, Pietro Campiglia, Fabiana Piscitelli and Eduardo Sommella

Talanta, 2025, 290, 127811
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Large-Scale Metabolite Imaging Gallery of Mouse Organ Tissues to Study Spatial Metabolism

Karl W. Smith, Antonia Fecke, Siva Swapna Kasarla and Prasad Phapale

J. Proteome Res., 2025, 24, 3105
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Improved MALDI-MS Imaging of Polar and 2H-Labeled Metabolites in Mouse Organ Tissues

Siva Swapna Kasarla, Antonia Fecke, Karl William Smith, Vera Flocke, Ulrich Flögel and Prasad Phapale

Anal. Chem., 2025, 97, 10720
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Single-Cell 5 μm-Resolution Dual-Polarity MALDI-MS Imaging without Matrix Reapplication

Yanyan Chen, Rui Shi, Jianing Wang, Chengyi Xie, Yuanyuan Song, Ruxin Li, Luyao Wen, Thomas Ka-Yam Lam, Zhu Yang and Zongwei Cai

Anal. Chem., 2025, 97, 17167
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Structure Elucidation for MALDI Mass Spectrometry Imaging Using Infrared Ion Spectroscopy

Jelle L. Schuurman, Lara van Tetering, Kas J. Houthuijs, Pieter Kooijman, Valerie Gailus-Durner, Stefanie Leuchtenberger, Helmut Fuchs, Martin Hrabe de Angelis, Udo F. H. Engelke, Dirk J. Lefeber, Clara D. M. van Karnebeek, Ron A. Wevers, Andrej Grgic, Benjamin Balluf, Michiel Vandenbosch, Rob Vreeken, Ron M. A. Heeren, Giel Berden, Jos Oomens and Jonathan Martens

Anal. Chem., 2025, 97, 13160
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MALDI mass spectrometry imaging in targeted drug discovery and development: The pros, the cons, and prospects in global omics techniques

Raphael N. Alolga, Shi-Lei Wang, Lian-Wen Qi, Hao Zang and Feng-Qing Huang

TrAC Trends in Analytical Chemistry, 2024, 178, 117860
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Mass spectrometry imaging for spatially resolved multi-omics molecular mapping

Hua Zhang, Kelly H. Lu, Malik Ebbini, Penghsuan Huang, Haiyan Lu and Lingjun Li

npj Imaging, 2024, 2
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MALDI-2-Enabled Oversampling for the Mass Spectrometry Imaging of Metabolites at Single-Cell Resolution

Jayden C. McKinnon, Rachelle Balez, Reuben S.E. Young, Mikayla L. Brown, Jeremy S. Lum, Liam Robinson, Mikhail E. Belov, Lezanne Ooi, Sara Tortorella, Todd W. Mitchell and Shane R. Ellis

J. Am. Soc. Mass Spectrom., 2024, 35, 2729
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Spatially resolved lipid disruption induced in Daphnia magna by environmentally relevant exposure to obesogens tributyltin and pyriproxyfen

Albert Menéndez-Pedriza, Cristina-María López, Eduardo Chicano-Gálvez, Joaquim Jaumot, Carlos Barata and Laia Navarro-Martín

Aquatic Toxicology, 2025, 287, 107521
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Mass spectrometry imaging in food safety and authenticity: Overcoming challenges and exploring opportunities

Sara Tortorella, Benjamin Bartels, Michele Suman, Ron M.A. Heeren and Laura Righetti

Trends in Food Science & Technology, 2025, 155, 104803
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