IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Shi-Yong Zhu, Chen-Xi Li, Yu-Xuan Tong, Ya-Ru Xu, Zhao-Yi Wang and Jin-Long Li

Food Funct., 2022, 13, 8871
DOI: 10.1039/D2FO01497A

Comparison of antagonistic effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR/PXR/Nrf2 pathways activation

Jing Ge, Kai Guo, Yan Huang, Palika Dias Morse, Cong Zhang, Mei-Wei Lv and Jin-Long Li

The Journal of Nutritional Biochemistry, 2022, 105, 108992
DOI: 10.1016/j.jnutbio.2022.108992

Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene

Yi Zhao, Xue-Nan Li, Hao Zhang, Jia-Gen Cui, Jia-Xin Wang, Ming-Shan Chen and Jin-Long Li

Journal of Hazardous Materials, 2022, 439, 129689
DOI: 10.1016/j.jhazmat.2022.129689

Lycopene alleviates di(2-ethylhexyl) phthalate-induced splenic injury by activating P62-Keap1-NRF2 signaling

Xue-Yan Dai, Shi-Yong Zhu, Jian Chen, Mu-Zi Li, Yi Zhao, Milton Talukder and Jin-Long Li

Food and Chemical Toxicology, 2022, 168, 113324
DOI: 10.1016/j.fct.2022.113324

New insight into phytometabolism and phytotoxicity mechanism of widespread plasticizer di (2-ethylhexyl) phthalate in rice plants

Xiaolong Yu, Huanhuan Xing, Jianteng Sun, Xiaodong Du, Guining Lu and Lizhong Zhu

Science of The Total Environment, 2023, 880, 163254
DOI: 10.1016/j.scitotenv.2023.163254

Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway

Jiten Singh, Ashok Jangra and Dinesh Kumar

Chemosphere, 2024, 356, 141922
DOI: 10.1016/j.chemosphere.2024.141922

Role of Toll-like Receptor/MyD88 Signaling in Lycopene Alleviated Di-2-ethylhexyl Phthalate (DEHP)-Induced Inflammatory Response

Xue-Yan Dai, Shi-Yong Zhu, Jian Chen, Mu-Zi Li, Milton Talukder and Jin-Long Li

J. Agric. Food Chem., 2022, 70, 10022
DOI: 10.1021/acs.jafc.2c03864

Disrupted microbiota-barrier-immune interaction in phthalates-mediated barrier defect in the duodenum

Tian-Ning Yang, Xue-Nan Li, Yu-Xiang Wang, Xiang-Yu Ma and Jin-Long Li

Chemosphere, 2022, 308, 136275
DOI: 10.1016/j.chemosphere.2022.136275

Xenobiotic-sensing nuclear receptors as targets for phthalates-induced lung injury and antagonism of lycopene

Yu-Sheng Shi, Yi Zhao, Xue-Nan Li, Mu-Zi Li and Jin-Long Li

Chemosphere, 2023, 312, 137265
DOI: 10.1016/j.chemosphere.2022.137265

Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2/Keap-1/NLRP3/Caspase-1 axis

Mu-Zi Li, Yi Zhao, Xue-Yan Dai, Milton Talukder and Jin-Long Li

The Journal of Nutritional Biochemistry, 2023, 113, 109266
DOI: 10.1016/j.jnutbio.2022.109266

Calcium homeostasis imbalance mediates DEHP induced mitochondrial damage in cerebellum and the antagonistic effect of lycopene

Jia-Gen Cui, Hao Zhang, Ming-Shan Chen, Jia-Xin Wang, Yi Zhao and Jin-Long Li

Science of The Total Environment, 2024, 954, 176351
DOI: 10.1016/j.scitotenv.2024.176351

Cadmium-induced splenic lymphocytes anoikis is not mitigated by activating Nrf2-mediated antioxidative defense response

Tian-Qi Guan, Bai-Hao Qiu, Hakberdi Nurmamedov, Milton Talukder, Mei-Wei Lv and Jin-Long Li

Journal of Inorganic Biochemistry, 2022, 234, 111882
DOI: 10.1016/j.jinorgbio.2022.111882

Lycopene Attenuates Di(2-ethylhexyl) Phthalate-Induced Mitochondrial Damage and Inflammation in Kidney via cGAS–STING Signaling

Mu-Zi Li, Xue-Yan Dai, Ying-Xin Zhao, Xiao-Wei Li, Yi Zhao and Jin-Long Li

J. Agric. Food Chem., 2023, 71, 569
DOI: 10.1021/acs.jafc.2c08351

Lycopene Ameliorate Atrazine-Induced Oxidative Damage in the B Cell Zone via Targeting the miR-27a-3p/Foxo1 Axis

Shi-Yong Zhu, Xue-Nan Li, Yi Zhao, Xue-Yan Dai, Jian-Ying Guo and Jin-Long Li

J. Agric. Food Chem., 2022, 70, 12502
DOI: 10.1021/acs.jafc.2c05103

Lycopene Alleviates Chronic Stress-Induced Liver Injury by Inhibiting Oxidative Stress-Mediated Endoplasmic Reticulum Stress Pathway Apoptosis in Rats

Ning Sun, Tianyuan Yang, Yulin Tang, Yuan Zhao, Hui Wang, Shuping Zhao, Haoyang Tan, Lin Li and Honggang Fan

J. Agric. Food Chem., 2022, 70, 14414
DOI: 10.1021/acs.jafc.2c06650

Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway

Yue-Qiang Huang, Yi-Xi Tang, Bai-Hao Qiu, Milton Talukder, Xue-Nan Li and Jin-Long Li

Food and Chemical Toxicology, 2022, 165, 113119
DOI: 10.1016/j.fct.2022.113119

Lycopene ameliorates Di-(2-ethylhexyl) phthalate-induced neurotoxicity in mice via the gut-brain axis

Li-Jian Chen, Yi Liu, Jia-Li Liu, Zhi-Jiang Chen, Wei Zhao, Ji-Hui Li, Clare Hsu, Long Chen, Jia-Hao Zeng, Xiu-Wen Li, Jian-Zheng Yang, Jia-Hao Li, Xiao-Li Xie, Shao-Hua Tao and Qi Wang

Phytomedicine, 2025, 145, 157057
DOI: 10.1016/j.phymed.2025.157057

Lycopene in male infertility

Sina Vakili, Mohammad Samare-Najaf, Aliasghar Karimi, Bahia Namavar Jahromi, Mohsen Mohit and Mohammad Hashem Hashempur

Naunyn-Schmiedeberg's Arch Pharmacol, 2025, 398, 4817
DOI: 10.1007/s00210-024-03520-x

Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis

Jia-Xin Wang, Yi Zhao, Ming-Shan Chen, Hao Zhang, Jia-Gen Cui and Jin-Long Li

Environmental Pollution, 2023, 317, 120717
DOI: 10.1016/j.envpol.2022.120717

Di-(2-ethylhexyl) phthalate exposure impairs cortical development in hESC-derived cerebral organoids

Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu and Xiaotang Fan

Science of The Total Environment, 2023, 865, 161251
DOI: 10.1016/j.scitotenv.2022.161251

Lycopene prevents Di-(2-ethylhexyl) phthalate-induced mitophagy and oxidative stress in mice heart via modulating mitochondrial homeostasis

Yue Shen, Lin Liu, Mu-Zi Li, Hao-Ran Wang, Yi Zhao and Jin-Long Li

The Journal of Nutritional Biochemistry, 2023, 115, 109285
DOI: 10.1016/j.jnutbio.2023.109285

Gap Junction Protein Connexin 43 as a Target Is Internalized in Astrocyte Neurotoxicity Caused by Di-(2-ethylhexyl) Phthalate

Ying-Xin Zhao, Yi-Xi Tang, Xiao-Han Sun, Shi-Yong Zhu, Xue-Yan Dai, Xue-Nan Li and Jin-Long Li

J. Agric. Food Chem., 2022, 70, 5921
DOI: 10.1021/acs.jafc.2c01635

Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice

Shi-Yong Zhu, Jun-Ze Jiang, Jia Lin, Lin Liu, Jian-Ying Guo and Jin-Long Li

Food and Chemical Toxicology, 2023, 174, 113655
DOI: 10.1016/j.fct.2023.113655

Optimization of lycopene extraction from tomato processing by-products with essential oils and effect of extract on oxidative stability of refined olive oil

Hajar El Basett and Hassan Hajjaj

Food Measure, 2024, 18, 9398
DOI: 10.1007/s11694-024-02888-x

TNF/TNFR1 Signaling Mediates DEHP-Induced Hepatocyte Pyroptosis via the GSDMD–mtROS Axis

Hao Zhang, Jia-Gen Cui, Ming-Shan Chen, Jia-Xin Wang, Xiao-Han Sun, Yi Zhao and Jin-Long Li

J. Agric. Food Chem., 2025
DOI: 10.1021/acs.jafc.4c11022

Drinking alkaline mineral water confers diarrhea resistance in maternally separated piglets by maintaining intestinal epithelial regeneration via the brain-microbe-gut axis

Jian Chen, Bi-Chen Zhao, Xue-Yan Dai, Ya-Ru Xu, Jian-Xun Kang and Jin-Long Li

Journal of Advanced Research, 2023, 52, 29
DOI: 10.1016/j.jare.2022.12.008

Metasilicate-based alkaline mineral water confers diarrhea resistance in maternally separated piglets via the microbiota-gut interaction

Jian Chen, Xiang-Wen Xu, Jian-Xun Kang, Bi-Chen Zhao, Ya-Ru Xu and Jin-Long Li

Pharmacological Research, 2023, 187, 106580
DOI: 10.1016/j.phrs.2022.106580

Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor

Yi Zhao, Hao Zhang, Jia-Gen Cui, Jia-Xin Wang, Ming-Shan Chen, Hao-Ran Wang, Xue-Nan Li and Jin-Long Li

Redox Biology, 2023, 59, 102584
DOI: 10.1016/j.redox.2022.102584

Cerebellar injury induced by cadmium via disrupting the heat-shock response

Shao-Shuai Bi, Milton Talukder, Xue-Tong Sun, Mei-Wei Lv, Jing Ge, Cong Zhang and Jin-Long Li

Environ Sci Pollut Res, 2022, 30, 22550
DOI: 10.1007/s11356-022-23771-6

Astragalus polysaccharide alleviates transport stress-induced heart injury in newly hatched chicks via ERS-UPR-autophagy dependent pathway

Jian Chen, Yi-Xi Tang, Jian-Xun Kang, Ya-Ru Xu, Ahmed Ibrahim Ahmed Elsherbeni, Hassan Bayoumi Ali Gharib and Jin-Long Li

Poultry Science, 2022, 101, 102030
DOI: 10.1016/j.psj.2022.102030

Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response

Shao-Shuai Bi, Milton Talukder, Hai-Tao Jin, Mei-Wei Lv, Jing Ge, Cong Zhang and Jin-Long Li

Animal Nutrition, 2022, 11, 402
DOI: 10.1016/j.aninu.2022.06.021

Transcriptome sequencing and metabolite analysis reveal the single and combined effects of microplastics and di-(2-ethylhexyl) phthalate on Peneaus vannamei

Qiang-Qiang Shi, Xiao-Qian Zhang, Ze-Ming Zhang, Ning-Bo Wang, Hua Liu, Rong-Rong Zhang, Ai-Li Sun, Jiong Chen and Xi-Zhi Shi

Science of The Total Environment, 2023, 867, 161549
DOI: 10.1016/j.scitotenv.2023.161549

DEHP triggers a damage severity grade increase in the jejunum in quail (Coturnix japonica) by disturbing nuclear xenobiotic receptors and the Nrf2-mediated defense response

Tian-Ning Yang, Xue-Nan Li, Xiao-Wei Li, Jin-Yang Li, Yue-Qiang Huang and Jin-Long Li

Environmental Toxicology and Pharmacology, 2022, 96, 104012
DOI: 10.1016/j.etap.2022.104012

Phthalate induces mitochondrial injury in cerebellum through Sirt1-PGC-1α and PINK1/Parkin-mediated signal pathways

Ling-Ge Cui, Lin Liu, Mu-Zi Li, Yu Zhu, Xiang-Yu Ma, Xue-Nan Li and Jin-Long Li

Life Sciences, 2023, 316, 121378
DOI: 10.1016/j.lfs.2023.121378

Novel Role of Hemeoxygenase-1 in Phthalate-Induced Renal Proximal Tubule Cell Ferroptosis

Ming-Shan Chen, Jia-Xin Wang, Hao Zhang, Jia-Gen Cui, Yi Zhao and Jin-Long Li

J. Agric. Food Chem., 2023, 71, 2579
DOI: 10.1021/acs.jafc.2c07762

Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases

Rasheed O. Sule, Gabriela Del Toro Rivera, Tanishq Vaidya, Emily Gartrell and Aldrin V. Gomes

Antioxidants, 2025, 14, 604
DOI: 10.3390/antiox14050604

Nano-Selenium Antagonized Cadmium-Induced Liver Fibrosis in Chicken

Xiao-Han Sun, Mei-Wei Lv, Ying-Xin Zhao, Hao Zhang, Muhammad Asmat Ullah Saleem, Yi Zhao and Jin-Long Li

J. Agric. Food Chem., 2023, 71, 846
DOI: 10.1021/acs.jafc.2c06562

Atrazine-induced oxidative damage via modulating xenobiotic-sensing nuclear receptors and cytochrome P450 systems in cerebrum and antagonism of lycopene

Xue-Yan Dai, Jia Lin, Shi-Yong Zhu, Jian-Ying Guo, Jia-Gen Cui and Jin-Long Li

Food and Chemical Toxicology, 2022, 170, 113462
DOI: 10.1016/j.fct.2022.113462