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Recent advances in luminescent metallacycles/metallacages for biomedical imaging and cancer therapy

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Designing novel Au(III) complexes based on the structure of diazepam: Achieving a multiaction mechanism against glioma

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Functional copper complexes with benzofurans tridentate ligand: Synthesis, crystal structure, DNA binding and anticancer studies

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Binuclear Biphenyl Organogold(III) Complexes: Synthesis, Photophysical and Theoretical Investigation, and Anticancer Activity

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The Gold(I) Complex with Plant Hormone Kinetin Shows Promising In Vitro Anticancer and PPARγ Properties

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Recent Update and Drug Target in Molecular and Pharmacological Insights into Autophagy Modulation in Cancer Treatment and Future Progress

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Investigation of the Cytotoxicity of Cu(II), Au(III), and Pd(II) Complexes with 2,4-Dithiouracil and 6-Propyl-2-thiouracil Derivatives

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Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity

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Erlotinib-Gold(I) Complex Induces Leukemia Cell DC Differentiation and Remodels the Immunosuppressive Microenvironment

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Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors

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Gold metallacages: Design principles and applications

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Antibiotics: A “GOLDen” promise?

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N-heterocyclic carbene gold(I) derivatives with long aliphatic side chains as potential anticancer agents in colon cancer

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Elaborately engineered Au(I)‐based AIEgens: Robust and broad‐spectrum elimination abilities toward drug‐resistant bacteria

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Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents

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A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

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Nanocarrier-Mediated Immunogenic Cell Death for Melanoma Treatment

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Tetrameric gold(III) complexes with L-histidine-containing dipeptides: crystal structure of the highly hydrated chloride salt of [Au(L-Val-L-His)] 4 2+ tetramer

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Long-Lived Immunogenic Cell Death Induced by a Water-Soluble Redox Active Au(I) Bis-N-Heterocyclic Carbene

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Synthesis and Catalytic Application of Ru(II) Complexes Supported by Zwitterionic Triazol(in)ium-5-dithiocarboxylates (MIC·CS2) and Isothiocyanates (MIC·CSNPh)

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Thioredoxin Reductase and Organometallic Complexes: A Pivotal System to Tackle Multidrug Resistant Tumors?

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Charge-Enhanced Reactivity of Esters by a Cationic Substituent

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Hydroxyl-augmented gold nanorods via lactone ring-opening alleviate cisplatin nephrotoxicity through Nrf2 activation

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Sustainable electrochemical gold dissolution process based on triboelectric nanogenerator

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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

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Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

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Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

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Synergistic Enhancement of Ferroptosis via Mitochondrial Accumulation and Photodynamic-Controlled Release of an Organogold(I) Cluster Prodrug

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Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

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Synthesis and Electrochemical Study of Gold(I) Carbene Complexes

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Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent—In Vitro and In Vivo Studies

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SERD-NHC-Au(I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer

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Silver(I) and gold(III) complexes with miconazole: The influence of the metal ion on the antimicrobial activity of the coordinated azole

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A DFT‐Based Protocol for Modeling the Structure and Reactivity of Gold(III) Complexes

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Tunable Nanomaterials of Intracellular Crystallization for In Situ Biolabeling and Biomedical Imaging

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Mixed N‐heterocyclic carbene and benzyl‐, phenethyl‐, and biphenylamine coordinated Pd complexes: Anticancer activities and stereo‐electronic effects

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Bio-responsive Au-miR-183 inhibitor enhances immunotherapy in hepatocellular carcinoma by inducing immunogenic cell death

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Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination

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NSAID–Au(I) Complexes Induce ROS-Driven DAMPs and Interpose Inflammation to Stimulate the Immune Response against Ovarian Cancer

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Benzimidazole-Based NHC Metal Complexes as Anticancer Drug Candidates: Gold(I) vs. Platinum(II)

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Synthesis, characterizations, and anticancer properties of bifunctional system based on gold(I) alkynyl and antipyrine

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Gold-Based Coronands as Hosts for M3+ Metal Ions: Ring Size Matters

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Gold Acyclic Diaminocarbene Complexes as Selective and Potent Agents for Multitarget Cancer Therapy

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Atomic Precise Gold Nanoclusters: Toward the Customize Synthesis, Precision Medicine

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Gold(I) complexes bearing EGFR-inhibiting ligands as anti-HCC agents through dual targeting of EGFR and TrxR

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Reaction Behavior of [1,3-Diethyl-4,5-diphenyl-1H-imidazol-2-ylidene] Containing Gold(I/III) Complexes against Ingredients of the Cell Culture Medium and the Meaning on the Potential Use for Cancer Eradication Therapy

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Circumventing Physicochemical Barriers of Cyclometalated Gold(III) Dithiocarbamate Complexes with Protein-Based Nanoparticle Delivery to Enhance Anticancer Activity

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Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets

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Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells

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Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells

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Development of Cu(II) 4-hydroxybenzoylhydrazone complexes that induce mitochondrial DNA damage and mitochondria-mediated apoptosis in liver cancer

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On the Interaction of Gold(III) Complexes with Human Serum Albumin

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Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes

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An efficient ICD inducer based on Ir(III) cyclometalated complex for anticancer and anti-migration effects towards cisplatin-resistant cancer cells

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Heteroleptic (NHC/MIC) Biscarbene Ag(I) and Au(I) Complexes: Synthesis, Characterization and Catalytic Applications

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Unveiling the cytotoxicity of a new gold(I) complex towards hepatocellular carcinoma by inhibiting TrxR activity

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A complex bearing TSPO PIGA ligand coordinated to the [Au(PEt3)]+ pharmacophore is highly cytotoxic against ovarian cancer cells

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A Self‐Adaptive Rhodium(I) Complex‐Based Nanoplatform with Type II Immunogenic Cell Death for Near‐Infrared Phosphorescence Imaging and Cancer Immunotherapy

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New gold (III) cyanide complex TGS 121 induces ER stress, proteasome inhibition and death of Ras-hyperactivated cells

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Gold-templated covalent targeting of the CysSec-dyad of thioredoxin reductase 1 in cancer cells

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Unveiling the anticancer potential of gold-sulfur complexes: Mechanisms, delivery strategies, and clinical progression

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Synthesis and anti-cancer investigations of copper(II) complexes based on adenine

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Revisiting the anticancer properties of phosphane(9-ribosylpurine-6-thiolato)gold(I) complexes and their 9H-purine precursors

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J Biol Inorg Chem, 2022, 27, 731
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A Conformationally Restricted Gold(III) Complex Elicits Antiproliferative Activity in Cancer Cells

Sailajah Gukathasan, Oluwatosin A. Obisesan, Setareh Saryazdi, Libby Ratliff, Sean Parkin, Robert B. Grossman and Samuel G. Awuah

Inorg. Chem., 2023, 62, 13118
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Unraveling the role of heavy metals xenobiotics in cancer: a critical review

Sourav Pal and Sayed Mohammed Firdous

Discov Onc, 2024, 15
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Novel NMR-Based Approach to Reveal the ‘Metabolic Fingerprint’ of Cytotoxic Gold Drugs in Cancer Cells

Veronica Ghini, Ana Isabel Tristán, Giorgio Di Paco, Lara Massai, Michele Mannelli, Tania Gamberi, Ignacio Fernández, Antonio Rosato, Paola Turano and Luigi Messori

J. Proteome Res., 2025, 24, 813
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Gold(I) complexes with NHC ligands functionalized with sulfoxide groups: Design, synthesis, in vitro studies and insights into the mechanism of action as anticancer drugs

Eleonora Zampieri, Chiara Donati, Victoria Mechrouk, Thierry Achard, Stéphane Bellemin-Laponnaz, Alessandro Dolmella, Cristina Marzano, Marco Baron, Valentina Gandin and Cristina Tubaro

Journal of Inorganic Biochemistry, 2025, 271, 112957
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Spontaneous Water-Promoted Self-Aggregation of a Hydrophilic Gold(I) Complex Due to Ligand Sphere Rearrangement

Ainhoa Rodríguez-Gobernado, Daniel Blasco, Miguel Monge and José M. López-de-Luzuriaga

Molecules, 2023, 28, 5680
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Research progress of natural product-conjugated platinum and gold complexes as potential antitumor agents

Meiyu Wang, Fuwei Li, Zhaoran Wang, Lin Lv and Wukun Liu

European Journal of Medicinal Chemistry, 2024, 280, 116956
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Protein Metalation by Medicinal Gold Compounds: Identification of the Main Features of the Metalation Process through ESI MS Experiments

Andrea Geri, Lara Massai and Luigi Messori

Molecules, 2023, 28, 5196
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Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle

Legna Colina‐Vegas, Mariana da Cruz B. Silva, Caroline de Souza Pereira, Ariane Isis Barros, Joaquim Araújo Nobrega, Maribel Navarro, Matthias Rottmann, Sarah D'Alessandro, Nicoletta Basilico, Alzir Azevedo Batista and Diogo R. M. Moreira

Chemistry A European J, 2023, 29
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Stability and Mitochondrial Localization of a Highly Cytotoxic Organogold(III) Complex with Diphosphine Ancillary Ligand in Lung Cancer Cells

Hester Blommaert, Clément Soep, Edwyn Remadna, Héloïse Dossmann, Murielle Salomé, Olivier Proux, Isabelle Kieffer, Jean‐Louis Hazemann, Sylvain Bohic, Michèle Salmain and Benoît Bertrand

Angew Chem Int Ed, 2025, 64
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A dinuclear gold(I) complex with bis(N-heterocyclic carbene) ligands potentiated immune responses against liver cancer via ROS-driven endoplasmic reticulum stress and ferroptosis

Qiuyue Lu, Min Shan, Jiaqi Yang, Zhongren Xu, Yueyue Lei and Wukun Liu

Chinese Chemical Letters, 2025, 110940
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Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs

M. Mustafa Cetin, Wenjing Peng, Daniel Unruh, Michael F. Mayer, Yehia Mechref and Kemal Yelekci

Front. Pharmacol., 2022, 13
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Chemical dissection of selective myeloid leukemia-1 inhibitors: How they were found and evolved

Luyao Wang, Yuxiang Chen, Maoqian Zhang, Jin Liu, Haozhe Li, Menghui Liu, Shuyun Wu, Yongmin Zhang, Wei Li and Bo Wang

European Journal of Medicinal Chemistry, 2025, 283, 117168
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Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space

Charles E. Greif, Owamagbe N. Orobator, Chibuzor Olelewe, Sean Parkin and Samuel G. Awuah

J. Med. Chem., 2025
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Linkage of the Dinuclear Gold(I) Complex Luminescence and Origin of Endocyclic Amino Group of Cyclic P2N2-Bridging Ligands

Igor D. Strelnik, Irina R. Dayanova, Bulat A. Faizullin, Asiya R. Mustafina, Tatiana P. Gerasimova, Ilya E. Kolesnikov, Daut R. Islamov, Igor A. Litvinov, Alexandra D. Voloshina, Anastasiia S. Sapunova, Aidar T. Gubaidullin, Elvira I. Musina and Andrey A. Karasik

Inorg. Chem., 2023, 62, 19474
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Rhodium-based metallodrugs for biological applications: current status and future perspectives

Wang Xiang, Suisui He, Tao Kuang, Jun Yin, Bin Hu, Chao Sun, Juan He, Jun Wang, Cui-Yun Yu and Hua Wei

Materials Today Bio, 2025, 33, 101941
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Shifting the Antibody–Drug Conjugate Paradigm: A Trastuzumab-Gold-Based Conjugate Demonstrates High Efficacy against Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Mouse Model

Afruja Ahad, Hiwa K. Saeed, Virginia del Solar, Javier E. López-Hernández, Alexa Michel, Joshua Mathew, Jason S. Lewis and Maria Contel

ACS Pharmacol. Transl. Sci., 2023, 6, 1972
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From the Design of Innovative Ti‐Pt Heterometallic Complexes to the Development of Highly Anti‐Proliferative Water‐Soluble Cationic Titanocenes

Audrey Trommenschlager, Nesrine Mabrouk, Cindy Racoeur, Amélie Godard, Cédric Balan, Laurence Dubrez, Ali Bettaïeb, Jérôme Husson, Pierre Le Gendre, Catherine Paul and Ewen Bodio

ChemBioChem, 2024
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Synthesis, characterization and anti-ovarian cancer activities of novel biphenyl-NHC-gold(I) complexes

Meiyu Wang, Yifei Li, Guizhi Jiang, Fuwei Li, Yunlong Lu and Wukun Liu

Journal of Organometallic Chemistry, 2024, 1013, 123167
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Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications

Jia Jiang, Xiaolin Xiong and Taotao Zou

Acc. Chem. Res., 2023, 56, 1043
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Simultaneous Activation of Immunogenic Cell Death and cGAS-STING Pathway by Liver- and Mitochondria-Targeted Gold(I) Complexes for Chemoimmunotherapy of Hepatocellular Carcinoma

Fuwei Li, Zhenfan Wen, Chuanxing Wu, Zhibin Yang, Zhaoran Wang, Wenjing Diao, Dahong Chen, Zhongren Xu, Yunlong Lu and Wukun Liu

J. Med. Chem., 2024, 67, 1982
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