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Health benefits of dietary chronobiotics: beyond resynchronizing internal clocks

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Capsaicin stability and bio-accessibility affected by complexation with high-amylose corn starch (HACS)

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Capsaicin ameliorates diet-induced disturbances of glucose homeostasis and gut microbiota in mice associated with the circadian clock

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Food Funct., 2023, 14, 1662
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Rapid detection of capsaicinoids via a Bi2S3/rGO/MWCNT-COOH-modified screen-printed electrode coupled with glass bead-assisted ultrasonic extraction

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Dietary supplementation with capsaicinoids alleviates obesity in mice fed a high-fat-high-fructose diet

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Recent progress in the ornamental pepper breeding in Indonesia

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Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

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Galacturonic acid-capsaicin prodrug for prolonged nociceptive-selective nerve blockade

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Preparation, pungency, and bioactivity of capsaicin: a review

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A comprehensive review of capsaicin: Biosynthesis, industrial productions, processing to applications, and clinical uses

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Capsaicin: a spicy way in liver disease

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Front. Pharmacol., 2024, 15
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Triple-Loaded Nanoemulsions Incorporating Coffee Extract for the Photoprotection of Curcumin and Capsaicin: Experimental and Computational Evaluation

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Capsaicin and Its Effects on Body Weight

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A comprehensive review on sustainable strategies for valorization of pepper waste and their potential application

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Lycium barbarum Polysaccharides and Capsaicin Inhibit Oxidative Stress, Inflammatory Responses, and Pain Signaling in Rats with Dextran Sulfate Sodium-Induced Colitis

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IJMS, 2022, 23, 2423
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Uncovering Novel Capsaicin Inhibitory Activity towards Human Carbonic Anhydrase Isoforms IX and XII by Combining In Silico and In Vitro Studies

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Antioxidants, 2023, 12, 1115
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Effect of Capsaicin and Dihydrocapsaicin in Capsicum on Myofibrillar Protein in Duck Meat

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Foods, 2023, 12, 3532
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Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

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Construction of double network gel for co-encapsulation of probiotics and capsaicin: Enhanced the physicochemical stability and controlled release

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Food Bioscience, 2024, 58, 103715
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Capsaicinoids and capsinoids of chilli pepper as feed additives in livestock production: Current and future trends

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Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis

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Natural Capsaicin, Honey and Its Combinatory effect in Complete Freund's adjuvant Induced Arthritis in Rats

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One-Step Encapsulation of Capsaicin into Chitosan–Oleic Acid Complex Particles: Evaluation of Encapsulation Ability and Stability

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Polymers, 2022, 14, 2163
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Capsicum Waste as a Sustainable Source of Capsaicinoids for Metabolic Diseases

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Foods, 2023, 12, 907
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Postharvest handling practices and mycotoxin occurrence along the dried berbere chilli pepper value chain: A case study from Northern Ethiopia

Neela Satheesh, Aditya Parmar, Solomon Workneh Fanta and Tanya Stathers

Journal of Stored Products Research, 2023, 103, 102157
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Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases

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Archives of Physiology and Biochemistry, 2024, 130, 38
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Physiochemical, microbiological and flavor characteristics of traditional Chinese fermented food Kaili Red Sour Soup

Dafei Li, Feixia Duan, Qiming Tian, Dingjiang Zhong, Xingyue Wang and Lirong Jia

LWT, 2021, 142, 110933
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Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver

Peng Cheng, Jiawei Wu, Gangfan Zong, Feihui Wang, Rui Deng, Ruizhi Tao, Cheng Qian, Yunlong Shan, Aiyun Wang, Yang Zhao, Zhonghong Wei and Yin Lu

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Extraction mechanism and bio-activities of capsaicinoids from lantern peppers placenta using deep eutectic solvents

Qin Yang, Alfred Mugambi Mariga, Liang Wen, Qiuhui Hu, Wenjian Yang, Minhao Xie, Jianhui Liu and Fei Pei

Food Chemistry, 2025, 464, 141773
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Capsaicin and Gut Microbiota in Health and Disease

Adrian Eugen Rosca, Mara Ioana Iesanu, Carmen Denise Mihaela Zahiu, Suzana Elena Voiculescu, Alexandru Catalin Paslaru and Ana-Maria Zagrean

Molecules, 2020, 25, 5681
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Self-assembly of phosphorylated capsaicin and curcumin for treatment of triple-negative breast cancer via combination of chemotherapy and photodynamic therapy

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Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 720, 137108
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Regulation of Pain Genes—Capsaicin vs Resiniferatoxin: Reassessment of Transcriptomic Data

Rajeev K. Singla, Adiba Sultana, Md. Shahin Alam and Bairong Shen

Front. Pharmacol., 2020, 11
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Preparation and Characterization of Capsaicin Encapsulated Polymeric Micelles and Studies of Synergism with Nicotinic Acids as Potential Anticancer Nanomedicines

Rawan Shamsheer, Suhair Sunoqrot, Violet Kasabri, Dana Shalabi, Rema Alkhateeb, Yusuf Alhiari, Riad Ababneh, Balqis Ikhmais and Hamza Abumansour

Journal of Pharmacy and Bioallied Sciences, 2023, 15, 107
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Capsaicin Shows Species and Strain-specific Activity: Investigation of the Antibacterial Effects on the Oral Pathogen Streptococcus mutans and the Oral Probiotics Streptococcus salivarius M18 and K12

Kader DOĞAN and Sinem TUNÇER

Hacettepe Journal of Biology and Chemistry, 2024, 52, 11
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Validation of Anti-pyretic-Derived Natural Products and Their Potentials for Drug Discovery

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Rev. Bras. Farmacogn., 2023, 33, 696
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Effects of capsaicin on intestinal health under antibiotic exposure

Qingying Fang, Leilei Yu, Fengwei Tian, Wei Chen and Qixiao Zhai

Food Science and Human Wellness, 2025, 14, 9250311
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Dietary factors and patterns in relation to risk of later‐onset ulcerative colitis in Chinese: A prospective study of 0.5 million people

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Biosensors and Sensing Systems for Rapid Analysis of Phenolic Compounds from Plants: A Comprehensive Review

Cristina Forzato, Veronica Vida and Federico Berti

Biosensors, 2020, 10, 105
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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

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Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?

Arpad Szallasi

Biomolecules, 2022, 12, 1783
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The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease

Kenneth Maiese

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Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis

Zi Han Wang, Wei Wei Du, Fei Yu Qian, Hao Yu Hou, Jia Le Deng, Xuan Rui Ren, Yi Pan, Yan Pan, Shao Chin Lee, Hong Mei Hu and Ji Zhong Zhao

Journal of Ethnopharmacology, 2025, 348, 119894
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Multiple Myeloma Inhibitory Activity of Plant Natural Products

Karin Jöhrer and Serhat Sezai Ҫiҫek

Cancers, 2021, 13, 2678
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Comprehensive phytochemical profiles and antioxidant activity of Korean local cultivars of red chili pepper (Capsicum annuum L.)

Hyemi Jang, Mira Choi and Kyoung-Soon Jang

Front. Plant Sci., 2024, 15
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Advances in the structural modification of Alzheimer’s disease drug – Huperzine A

Xiaoxin Zhu, Jin-Bu Xu, Feng Gao and Lin-Xi Wan

Bioorganic Chemistry, 2025, 154, 108012
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Capsaicin and cancer: Guilty as charged or innocent until proven guilty?

Arpad Szallasi

Temperature, 2023, 10, 35
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Applications of capsaicin in food industry: functionality, utilization and stabilization

Aida Rezazadeh, Hamed Hamishehkar, Ali Ehsani, Zahra Ghasempour and Ehsan Moghaddas Kia

Critical Reviews in Food Science and Nutrition, 2023, 63, 4009
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Pharmacological approaches to treat intestinal pain

Mikolaj Swierczynski, Adam Makaro, Agata Grochowska and Maciej Salaga

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Microneedle-Mediated Treatment of Obesity

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Pharmaceutics, 2025, 17, 248
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Capsaicin from chili peppers and its analogues and their valued applications: An updated literature review

Na Wang, Xiang Zhou, Taihong Zhang, Wujun Jian, Zhaoju Sun, Puying Qi, Yumei Feng, Hongwu Liu, Liwei Liu and Song Yang

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Nanocarrier-enabled delivery of natural antiobesity agents

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Capsaicin Mitigates Reverbα-Involved Lipid Metabolism Disorder in HepG2 Cells and Obese Mice through a Trpv1-Dependent Mechanism

Ting Cao, Chi-Tang Ho, Wenshuo Wang and Muwen Lu

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Relationship between acupuncture and transient receptor potential vanilloid: Current and future directions

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Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-κB and PI3K/AKT/mTOR Pathways

Hui Chen, Na Li, Xiang Zhan, Ting Zheng, Xinzhou Huang, Qianglin Chen, Zihao Song, Fei Yang, Hao Nie, Yanxiang Zhang, Bing Zheng and Quan Gong

JIR, 2021, Volume 14, 5291
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A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease

Deborah Inyang, Tasneem Saumtally, Chinelo Nonyerem Nnadi, Sharmila Devi and Po-Wah So

IJMS, 2023, 24, 10176
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Mediterranean herbs, spices, and medicinal plants—Natural remedies and rich sources of bioactive compounds

Anita Trajkovska‐Broach and Anka Trajkovska Petkoska

JSFA Reports, 2023, 3, 4
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Sulfonation of Capsaicin by sulfotransferases produces an anti-inflammatory metabolite with NF-κB pathway modulatory activity

Wanyu Hu, Hongyu Wang, Lili Gan, Yating Lin, Yufang Fu, Weiling Tan, Xianrui Dou and Ling Ye

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Regulatory Role of Bioactive Compounds from Natural Spices on Mitochondrial Function

Liguang Han, Chi-Tang Ho and Muwen Lu

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Novel capsaicin hollow salt constructed by nanoemulsion-spray drying strategy with enhanced antioxidant stability and stronger salty sensation

Yi Ma, Yuanda Sun, Shasha Huang, Chenglong Sun, Haitao Wang and Mingqian Tan

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Regulation of miRNA-155-5p ameliorates NETosis in pulmonary fibrosis rat model via inhibiting its target cytokines IL-1β, TNF-α and TGF-β1

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Bioactive compounds and antioxidant activity in three types of Korean watery kimchi

Hyosun Park, Suna Kim, Jaecheol Kim, KyeongJin Lee and BoKyung Moon

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Effects of Capsaicin on Glucose Uptake and Consumption in Hepatocytes

Haolong Zeng, Nian Shi, Wenlei Peng, Qing Yang, Jingnan Ren, Hong Yang, Lingling Chen, Yijie Chen and Jun Guo

Molecules, 2023, 28, 5258
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Effect of Different Addition Amounts of Capsaicin on the Structure, Oxidation Sites, and Gel Properties of Myofibrillar Proteins under Oxidative Conditions

Dong Zhang, Zhi-Cheng Wu, Jing-Bing Xu, Nan-Xi Huang, Yong Tang, Chang Su, Jie Tang and Hong-Jun Li

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Health benefits of bioactive components in pungent spices mediated via the involvement of TRPV1 channel

Muwen Lu, Chengyu Chen, Jie Xiao, Yaqi Lan, Yong Cao, Qingrong Huang and Chi-Tang Ho

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Evaluation of binding mechanism of dietary phytochemical, capsaicin, with human transferrin: targeting neurodegenerative diseases therapeutics

Mohammed Alrouji, Fahad A. Alhumaydhi, Kumar Venkatesan, Sharaf E. Sharaf, Moyad Shahwan and Anas Shamsi

Front. Pharmacol., 2024, 15
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Chile (Capsicum spp.) as Food-Medicine Continuum in Multiethnic Mexico

Araceli Aguilar-Meléndez, Marco Antonio Vásquez-Dávila, Gladys Isabel Manzanero-Medina and Esther Katz

Foods, 2021, 10, 2502
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Characterization of the interaction between capsaicin and porcine myofibrillar proteins

Haifan Wang, Lerong Qin, Yujie Wang, Lijuan Peng, E Liao, Hongyan Lu, Aijun Zou, Caixian Zou and Haibin Wang

LWT, 2023, 184, 115031
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Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Therapeutic Effects of Capsaicin on Lipopolysaccharide-Induced Acute Lung Injury

Peihui Liu, Jindou Hao, Jie Zhao, Rong Zou, Juan Han, Jia Tian, Wanqu Liu, Hao Wang and Joilson O. Martins

Mediators of Inflammation, 2022, 2022, 1
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The ameliorative effects of capsidiol isolated from elicited Capsicum annuum on mouse splenocyte immune responses and neuroinflammation

Eun‐Ju Yang and Kyung‐Sik Song

Phytotherapy Research, 2021, 35, 1597
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Encapsulation of Capsaicin in Oil‐In‐Water Nanoemulsion: Optimization by a Mixture Design and Its Application in Merguez Sausage Preservation

Eya Soussi, Khouloud Rigane, Anis Ben Hsouna, Miroslava Kačániová, Wissem Mnif, Zaina Algarni and Moncef Chouaibi

Food Science & Nutrition, 2025, 13
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Capsaicin encapsulated in W/O/W double emulsions fabricated via ethanol-induced pectin gelling: Improvement of bioaccessibility and reduction of irritation

Jingxing He, Xiaolin Wu, Youfa Xie, Yi Gao, David Julian McClements, Lu Zhang, Liqiang Zou and Wei Liu

International Journal of Biological Macromolecules, 2023, 235, 123899
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Capsaicin Ameliorates the Cyclophosphamide-Induced Cardiotoxicity by Inhibiting Free Radicals Generation, Inflammatory Cytokines, and Apoptotic Pathway in Rats

Rayan A. Ahmed, Mohammad Firoz Alam, Saeed Alshahrani, Abdulmajeed M. Jali, Abdullah M. Qahl, Mohammad Khalid, Hisham M. A. Muzafar, Hussain N. Alhamami and Tarique Anwer

Life, 2023, 13, 786
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Protective effect of peroral capsaicin administration in ethanol-induced gastric ulcer model in rats.

Mete Keçeci, Meryem Akpolat Ferah, Habib Khoshvaghti and Osman Cengil

Ege Tıp Dergisi, 2025, 64, 98
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Characterization of capsaicinoids and their analogues using feature-based molecular networking analysis

Hyemi Jang, Mira Choi and Kyoung-Soon Jang

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Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Maged Alkanad, Umme Hani, Annegowda H V, Mohammed Ghazwani, Nazima Haider, Riyaz Ali M. Osmani, Pandareesh M D, Hamsalakshmi and Rajeev Bhat

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Effects of Lentilactobacillus buchneri and Kazachstania bulderi on the Quality and Flavor of Guizhou Fermented Red Sour Soup

Na Liu, Xiuli Li, Yue Hu, Likang Qin, Aiming Bao, Weijun Qin and Song Miao

Foods, 2023, 12, 3753
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Effects of Storage Temperature at the Early Postharvest Stage on the Firmness, Bioactive Substances, and Amino Acid Compositions of Chili Pepper (Capsicum annuum L.)

Yuan Cheng, Chengan Gao, Shaodan Luo, Zhuping Yao, Qingjing Ye, Hongjian Wan, Guozhi Zhou and Chaochao Liu

Metabolites, 2023, 13, 820
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Computer-aided ligand identification of capsaicinoids and their potential functions in metabolic diseases

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Effect of Capsaicin Addition on Antioxidant Capacity, Immune Performance and Upper Respiratory Microbiota in Nursing Calves

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Microorganisms, 2023, 11, 1903
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Capsaicin derivatives: Synthesis and biological activity

Shun Liu, Xing Zheng, Jiao Wu, Yiqian Zeng, Xueni Wei, Anfeng Li and Xu Yao

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A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study

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Plant-Derivatives Small Molecules with Antibacterial Activity

Sana Alibi, Dámaso Crespo and Jesús Navas

Antibiotics, 2021, 10, 231
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Fabrication and Characterization of Whey Protein—Citrate Mung Bean Starch—Capsaicin Microcapsules by Spray Drying with Improved Stability and Solubility

Xiuyun Zhang, Bo Zhang, Xiangzhen Ge, Huishan Shen, Xiangxiang Sun, Qian Zhang, Yifan Lu, Zhuangzhuang Sun and Wenhao Li

Foods, 2022, 11, 1049
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Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

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Gels, 2024, 10, 45
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A review of the patent literature surrounding TRPV1 modulators

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Capsaicin functions as an androgen receptor antagonist inhibiting the growth of prostate cancer in cellular and mice models

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A green approach for the sustained-intestinal delivery of red chili (Capsicum annum L) extracted capsaicinoids with enhanced bioavailability

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Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota

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The degradation and antioxidant activities of capsaicinoid pungent dietary components from peppers and gingers: The mechanistic insights

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Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells

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J. Agric. Food Chem., 2022, 70, 794
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Emerging trends in nano-bioactive-mediated mitochondria-targeted therapeutic stratagems using polysaccharides, proteins and lipidic carriers

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Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

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Cells, 2023, 12, 2595
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Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas

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Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages

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Overcoming the Challenges of Phytochemicals in Triple Negative Breast Cancer Therapy: The Path Forward

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Therapeutic Potential of Capsaicin in Various Neurodegenerative Diseases with Special Focus on Nrf2 Signaling

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CPB, 2024, 25, 1693
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Capsaicinoid Profiles, Phenolic Content, and Antioxidant Properties of Chili Peppers Grown in Urban Settings

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IJMS, 2025, 26, 4916
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TRPV1-Targeted Drugs in Development for Human Pain Conditions

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The Endocannabinoid Peptide RVD-Hemopressin Is a TRPV1 Channel Blocker

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Nonpungent N-AVAM Capsaicin Analogues and Cancer Therapy

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Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System

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A literature-based overview on chemistry, pharmacology, molecular docking and nanotechnological advancements of capsaicin including potential impact on pharmacological action of other drugs with mechanistic insight

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Microencapsulation of Capsaicin in Chitosan Microcapsules: Characterization, Release Behavior, and Pesticidal Properties against Tribolium castaneum (Herbst)

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Single‐cell RNA sequencing reveals the effects of capsaicin in the treatment of sepsis‐induced liver injury

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The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight

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Combining Ability of Capsicum annuum Hybrid for Antioxidant Activities, Polyphenol Content, α-Glucosidase Inhibitory, Yield, and Yield Components

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Capsaicin: Emerging Pharmacological and Therapeutic Insights

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Evaluation of electron beam irradiation on the microbiological, phytochemicals, and aromatic profiles of three paprika (Capsicum annuum L.) varieties

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Mechanism investigation and experiment validation of capsaicin on uterine corpus endometrial carcinoma

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The Genus Capsicum: A Review of Bioactive Properties of Its Polyphenolic and Capsaicinoid Composition

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Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

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Current insights on the effects of medicinal plants in the management of obesity and infectious diseases: An update from 2020

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Biochemical and Yield Component of Hybrid Chili (Capsicum annuum L.) Resulting from Full Diallel Crosses

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Design, Synthesis and Biological Evaluation of Novel Capsaicin Analogues Containing Heterocyclic Fatty Acids

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Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress

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Encapsulation of hydrophobic capsaicin within the aqueous phase of water-in-oil high internal phase emulsions: Controlled release, reduced irritation, and enhanced bioaccessibility

Xiaolin Wu, Na Xu, Ce Cheng, David Julian McClements, Xing Chen, Liqiang Zou and Wei Liu

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Ferroptosis, Iron Metabolism, and Forkhead Transcription Factors (FoxOs)

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