Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics

Shichao Lin, Yilong Liu, Mingxia Zhang, Xing Xu, Yingwen Chen, Huimin Zhang and Chaoyong Yang

Lab Chip, 2021, 21, 3829
DOI: 10.1039/D1LC00607J

A State-of-the-Art Roadmap for Biomarker-Driven Drug Development in the Era of Personalized Therapies

Victoria Serelli-Lee, Kazumi Ito, Akira Koibuchi, Takahiko Tanigawa, Takayo Ueno, Nobuko Matsushima and Yasuhiko Imai

JPM, 2022, 12, 669
DOI: 10.3390/jpm12050669

Highly parallel and efficient single cell mRNA sequencing with paired picoliter chambers

Mingxia Zhang, Yuan Zou, Xing Xu, Xuebing Zhang, Mingxuan Gao, Jia Song, Peifeng Huang, Qin Chen, Zhi Zhu, Wei Lin, Richard N. Zare and Chaoyong Yang

Nat Commun, 2020, 11
DOI: 10.1038/s41467-020-15765-0

Single-Cell Transcriptomics: Current Methods and Challenges in Data Acquisition and Analysis

Asif Adil, Vijay Kumar, Arif Tasleem Jan and Mohammed Asger

Front. Neurosci., 2021, 15
DOI: 10.3389/fnins.2021.591122

Single-Cell Transcriptome Analysis in Plants: Advances and Challenges

Rahul Shaw, Xin Tian and Jian Xu

Molecular Plant, 2021, 14, 115
DOI: 10.1016/j.molp.2020.10.012

An Integrated Multi-Omics and Artificial Intelligence Framework for Advance Plant Phenotyping in Horticulture

Danuta Cembrowska-Lech, Adrianna Krzemińska, Tymoteusz Miller, Anna Nowakowska, Cezary Adamski, Martyna Radaczyńska, Grzegorz Mikiciuk and Małgorzata Mikiciuk

Biology, 2023, 12, 1298
DOI: 10.3390/biology12101298

Aging mechanisms—A perspective mostly from Drosophila

Amy Tsurumi and Willis X. Li

Advanced Genetics, 2020, 1
DOI: 10.1002/ggn2.10026

Pro-biomics: Omics Technologies To Unravel the Role of Probiotics in Health and Disease

Despoina Eugenia Kiousi, Marina Rathosi, Margaritis Tsifintaris, Pelagia Chondrou and Alex Galanis

Advances in Nutrition, 2021, 12, 1802
DOI: 10.1093/advances/nmab014

Analyzing Modern Biomolecules: The Revolution of Nucleic-Acid Sequencing – Review

Gabriel Dorado, Sergio Gálvez, Teresa E. Rosales, Víctor F. Vásquez and Pilar Hernández

Biomolecules, 2021, 11, 1111
DOI: 10.3390/biom11081111

Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single‐cell RNA sequencing analyses

Jorge A. Tzec‐Interián, Daianna González‐Padilla and Elsa B. Góngora‐Castillo

Quant. Biol., 2025, 13
DOI: 10.1002/qub2.78

Advances in application of single-cell RNA sequencing in cardiovascular research

Yue Hu, Ying Zhang, Yutong Liu, Yan Gao, Tiantian San, Xiaoying Li, Sensen Song, Binglong Yan and Zhuo Zhao

Front. Cardiovasc. Med., 2022, 9
DOI: 10.3389/fcvm.2022.905151

Application of single-cell multi-omics approaches in horticulture research

Jun Zhang, Mayra Ahmad and Hongbo Gao

Mol Horticulture, 2023, 3
DOI: 10.1186/s43897-023-00067-y

Omics research in vascular calcification

Meng Duan, Wen-Li Zhao, Le Zhou, Petr Novák, Xiao Zhu and Kai Yin

Clinica Chimica Acta, 2020, 511, 319
DOI: 10.1016/j.cca.2020.10.022

Decoding Expression Dynamics of Protein and Transcriptome at the Single-Cell Level in Paired Picoliter Chambers

Xing Xu, Mingxia Zhang, Xuebing Zhang, Yilong Liu, Linfeng Cai, Qianqian Zhang, Qin Chen, Li Lin, Shichao Lin, Yanling Song, Zhi Zhu and Chaoyong Yang

Anal. Chem., 2022, 94, 8164
DOI: 10.1021/acs.analchem.1c05312

Single‐Cell Sequencing Methodologies: From Transcriptome to Multi‐Dimensional Measurement

Yingwen Chen, Jia Song, Qingyu Ruan, Xi Zeng, Lingling Wu, Linfeng Cai, Xuanqun Wang and Chaoyong Yang

Small Methods, 2021, 5
DOI: 10.1002/smtd.202100111

Omics-Integrated Approach (Metabolomics, Proteomics and Lipidomics) to Assess the Quality Control of Aquatic and Seafood Products

Marianthi Sidira, Sofia Agriopoulou, Slim Smaoui and Theodoros Varzakas

Applied Sciences, 2024, 14, 10755
DOI: 10.3390/app142210755

A Highly Sensitive, Accurate, and Automated Single-Cell RNA Sequencing Platform with Digital Microfluidics

Xing Xu, Qianqian Zhang, Jia Song, Qingyu Ruan, Weidong Ruan, Yujie Chen, Jian Yang, Xuebing Zhang, Yanling Song, Zhi Zhu and Chaoyong Yang

Anal. Chem., 2020, 92, 8599
DOI: 10.1021/acs.analchem.0c01613

Omics technologies as powerful approaches to unravel colorectal cancer complexity and improve its management

Zaynab Fatfat, Marwa Hussein, Maamoun Fatfat and Hala Gali-Muhtasib

Molecules and Cells, 2025, 48, 100200
DOI: 10.1016/j.mocell.2025.100200

New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data

Xin Shao, Xiaoyan Lu, Jie Liao, Huajun Chen and Xiaohui Fan

Protein Cell, 2020, 11, 866
DOI: 10.1007/s13238-020-00727-5

cdh23 affects congenital hearing loss through regulating purine metabolism

Shu Yang, Bing-Lin Xie, Xiao-ping Dong, Ling-xiang Wang, Gang-hua Zhu, Tian Wang, Wei-jing Wu, Ruo-sha Lai, Rong Tao, Min-xin Guan, Fang-yi Chen, Dong-hui Tan, Zhong Deng, Hua-ping Xie, Yong Zeng, Zi-an Xiao and Ding-hua Xie

Front. Mol. Neurosci., 2023, 16
DOI: 10.3389/fnmol.2023.1079529

Microfluidic Single‐Cell Omics Analysis

Xing Xu, Junxia Wang, Lingling Wu, Jingjing Guo, Yanling Song, Tian Tian, Wei Wang, Zhi Zhu and Chaoyong Yang

Small, 2020, 16
DOI: 10.1002/smll.201903905

Multiplexed Label‐Free Biomarker Detection by Targeted Disassembly of Variable‐Length DNA Payload Chains

Matthew Aquilina and Katherine E. Dunn

Analysis & Sensing, 2023, 3
DOI: 10.1002/anse.202200082

Single-cell transcriptomics: a novel precision medicine technique in nephrology

Jisoo Kim and Jihwan Park

Korean J Intern Med, 2021, 36, 479
DOI: 10.3904/kjim.2020.415

Plant biotechnology research with single-cell transcriptome: recent advancements and prospects

Muhammad Ali, Tianxia Yang, Hai He and Yu Zhang

Plant Cell Rep, 2024, 43
DOI: 10.1007/s00299-024-03168-0

SIEVE: identifying robust single cell variable genes for single-cell RNA sequencing data

Yinan Zhang, Xiaowei Xie, Peng Wu and Ping Zhu

Blood Science, 2021, 3, 35
DOI: 10.1097/BS9.0000000000000072

Omics research in vascular calcification

Meng Duan, Wen-Li Zhao, Le Zhou, Petr Novák, Xiao Zhu and Kai Yin

Clinica Chimica Acta, 2020, 511, 198
DOI: 10.1016/j.cca.2020.10.021

High-throughput microfluidic droplets in biomolecular analytical system: A review

Lexiang Zhang, Rokshana Parvin, Mingshuo Chen, Dingmeng Hu, Qihui Fan and Fangfu Ye

Biosensors and Bioelectronics, 2023, 228, 115213
DOI: 10.1016/j.bios.2023.115213

Status and Potential of Single‐Cell Transcriptomics for Understanding Plant Development and Functional Biology

Muhammad Munir Iqbal, Bhavna Hurgobin, Andrea Lisa Holme, Rudi Appels and Parwinder Kaur

Cytometry Pt A, 2020, 97, 997
DOI: 10.1002/cyto.a.24196

Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution

Dragana Miloradovic, Dragica Pavlovic, Marina Gazdic Jankovic, Sandra Nikolic, Milos Papic, Nevena Milivojevic, Miodrag Stojkovic and Biljana Ljujic

Front. Cell Dev. Biol., 2021, 9
DOI: 10.3389/fcell.2021.709183

Multi Omics Applications in Biological Systems

Cristian D. Gutierrez Reyes, Gerardo Alejo-Jacuinde, Benjamin Perez Sanchez, Jesus Chavez Reyes, Sherifdeen Onigbinde, Damir Mogut, Irma Hernández-Jasso, Denisse Calderón-Vallejo, J. Luis Quintanar and Yehia Mechref

CIMB, 2024, 46, 5777
DOI: 10.3390/cimb46060345

Strategic Tasks and Prospects for the Development of the Resource Base of Healthcare and Health Saving through the Prism of Personalized and Precision Medicine

S. V. Suchkov, H. Abe, A. I. Berezhnoy, S. Murphy, V. S. Polyakova, M. V. Vasiliev, A. P. Ovchinnikov, D. Smith, V. M. Zemskov, A. S. Revishvili, V. S. Demidova, D. Scherman, A. P. Glinushkin, A. M. Zemskov, P. Barach and A. N. Suvorov

Uspehi sovremennoj biologii, 2024, 144, 137
DOI: 10.31857/S0042132424020021

Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma. b. brucei infected CD1 mouse brains

Paul Montague, Barbara Bradley, Jean Rodgers, Peter G. E. Kennedy and Margaret A. Phillips

PLoS Negl Trop Dis, 2021, 15, e0009892
DOI: 10.1371/journal.pntd.0009892

Quantum Chemistry Calculations for Metabolomics

Ricardo M. Borges, Sean M. Colby, Susanta Das, Arthur S. Edison, Oliver Fiehn, Tobias Kind, Jesi Lee, Amy T. Merrill, Kenneth M. Merz, Thomas O. Metz, Jamie R. Nunez, Dean J. Tantillo, Lee-Ping Wang, Shunyang Wang and Ryan S. Renslow

Chem. Rev., 2021, 121, 5633
DOI: 10.1021/acs.chemrev.0c00901

From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care

Masaru Tanaka

Biomedicines, 2025, 13, 167
DOI: 10.3390/biomedicines13010167

Magnetic Particles for CTC Enrichment

Peng Liu, Pascal Jonkheijm, Leon W. M. M. Terstappen and Michiel Stevens

Cancers, 2020, 12, 3525
DOI: 10.3390/cancers12123525

Advances of single-cell genomics and epigenomics in human disease: where are we now?

Rizqah Kamies and Celia P. Martinez-Jimenez

Mamm Genome, 2020, 31, 170
DOI: 10.1007/s00335-020-09834-4

Introducing “Identification Probability” for Automated and Transferable Assessment of Metabolite Identification Confidence in Metabolomics and Related Studies

Thomas O. Metz, Christine H. Chang, Vasuk Gautam, Afia Anjum, Siyang Tian, Fei Wang, Sean M. Colby, Jamie R. Nunez, Madison R. Blumer, Arthur S. Edison, Oliver Fiehn, Dean P. Jones, Shuzhao Li, Edward T. Morgan, Gary J. Patti, Dylan H. Ross, Madelyn R. Shapiro, Antony J. Williams and David S. Wishart

Anal. Chem., 2025, 97, 1
DOI: 10.1021/acs.analchem.4c04060

Dispen-Seq: a single-microparticle dispenser based strategy towards flexible cell barcoding for single-cell RNA sequencing

Tian Tian, Yingwen Chen, Yunpeng Bi, Xingrui Li, MingXuan Gao, Xuebing Zhang, Weidong Ruan, Jia Song, Xing Xu, Lingling Wu, Zhi Zhu, Yanling Song and Chaoyong Yang

Sci. China Chem., 2021, 64, 650
DOI: 10.1007/s11426-020-9925-8

Strategic Tasks and Prospects for the Development of the Resource Base of Healthcare and Health Saving through the Prism of Personalized and Precision Medicine

S. V. Suchkov, H. Abe, A. I. Berezhnoy, S. Murphy, V. S. Polyakova, M. V. Vasiliev, A. P. Ovchinnikov, D. Smith, V. M. Zemskov, A. S. Revishvili, V. S. Demidova, D. Scherman, A. P. Glinushkin, A. M. Zemskov, P. Barach and A. N. Suvorov

Biol Bull Rev, 2024, 14, 410
DOI: 10.1134/S2079086424600073

Polymerase Chain Reaction Chips for Biomarker Discovery and Validation in Drug Development

Dang-Khoa Vo and Kieu The Loan Trinh

Micromachines, 2025, 16, 243
DOI: 10.3390/mi16030243

Multi‐omics technologies and molecular biomarkers in brain tumor‐related epilepsy

Yaoqiang Du, Rusong Li, Danqing Fu, Biqin Zhang, Ailin Cui, Yutian Shao, Zeyu Lai, Rongrong Chen, Bingyu Chen, Zhen Wang, Wei Zhang and Lisheng Chu

CNS Neurosci Ther, 2024, 30
DOI: 10.1111/cns.14717