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Kohei Fuchibe, Shumpei Watanabe, Go Takao and Junji Ichikawa

Org. Biomol. Chem., 2019, 17, 5047
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New synthetic approaches for the construction of difluoromethylated architectures

Zhou Sun, Xue-Song Zhang, Shao-Wei Bian, Chun Zhang, Ya-Ping Han and Yong-Min Liang

Org. Biomol. Chem., 2025, 23, 3029
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Nickel-catalysed fluoromethylation reactions

Pravya P. Nair, Rose Mary Philip and Gopinathan Anilkumar

Catal. Sci. Technol., 2021, 11, 6317
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Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling

Han Yin, Jie Sheng, Kai-Fan Zhang, Zi-Qi Zhang, Kang-Jie Bian and Xi-Sheng Wang

Chem. Commun., 2019, 55, 7635
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Recent progress on selective deconstructive modes of halodifluoromethyl and trifluoromethyl-containing reagents

Xingxing Ma and Qiuling Song

Chem. Soc. Rev., 2020, 49, 9197
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Copper-mediated cascade radical cyclization of olefins with naphthalenyl iododifluoromethyl ketones

Peng Peng, Guo-zhi Huang, Ying-xin Sun, Xing Wang, Jing-jing Wu and Fan-hong Wu

Org. Biomol. Chem., 2019, 17, 6426
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Nickel-catalyzed fluoroethylation of arylboronic acids via Suzuki-type coupling

Yi Yang, Junjie Cai, Gen Luo, Yan Jiang, Yumei Su, Yang Su, Chaolin Li, Yubin Zheng, Jijiao Zeng and Yingle Liu

Org. Chem. Front., 2019, 6, 1463
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Exploiting the trifluoroethyl group as a precatalyst ligand in nickel-catalyzed Suzuki-type alkylations

Yi Yang, Qinghai Zhou, Junjie Cai, Teng Xue, Yingle Liu, Yan Jiang, Yumei Su, Lungwa Chung and David A. Vicic

Chem. Sci., 2019, 10, 5275
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Recent advances on non-precious metal-catalysed fluorination, difluoromethylation, trifluoromethylation, and perfluoroalkylation of N-heteroarenes

Purushotam, Atanu Bera and Debasis Banerjee

Org. Biomol. Chem., 2023, 21, 9298
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Late-stage difluoromethylation: concepts, developments and perspective

Jeroen B. I. Sap, Claudio F. Meyer, Natan J. W. Straathof, Ndidi Iwumene, Christopher W. am Ende, Andrés A. Trabanco and Véronique Gouverneur

Chem. Soc. Rev., 2021, 50, 8214
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Palladium‐Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

Fei Pan, Gregory B. Boursalian and Tobias Ritter

Angewandte Chemie, 2018, 130, 17113
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Direct and Regioselective C–H Oxidative Difluoromethylation of Heteroarenes

Sheng-Qing Zhu, Yin-Li Liu, Huan Li, Xiu-Hua Xu and Feng-Ling Qing

J. Am. Chem. Soc., 2018, 140, 11613
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Ex Situ Generation of Difluorodiazoethane (CF2HCHN2): Application in the Regioselective Synthesis of CF2H-Containing Pyrazoles

Jian-Shu Wang, Kai-Shun Huang, Wen-Yong Han, Bao-Dong Cui, Nan-Wei Wan and Yong-Zheng Chen

Org. Lett., 2019, 21, 8751
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Photocatalyzed Cyanodifluoromethylation of Alkenes

Min Zhang, Jin‐Hong Lin and Ji‐Chang Xiao

Angewandte Chemie, 2019, 131, 6140
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Nickel‐Catalyzed Carbofluoroalkylation of 1,3‐Enynes to Access Structurally Diverse Fluoroalkylated Allenes

Kai‐Fan Zhang, Kang‐Jie Bian, Chao Li, Jie Sheng, Yan Li and Xi‐Sheng Wang

Angewandte Chemie, 2019, 131, 5123
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Efficient enantioselective synthesis of CF2H-containing dispiro [benzo[b]thiophene-pyrrolidine-pyrazole]s via organocatalytic cycloaddition

Yabo Deng, Changyan Yang, Siyu Shi, Yisheng Cao, Pengfei Jia, Yuan Li, Jinqi Huang and Wenjin Yan

Tetrahedron, 2023, 144, 133580
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Nickel-Catalyzed Aromatic Cross-Coupling Difluoromethylation of Grignard Reagents with Difluoroiodomethane

Hirotaka Motohashi and Koichi Mikami

Org. Lett., 2018, 20, 5340
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Olefin Bifunctionalization: A Visible‐light Photoredox‐catalyzed Aryl Alkoxylation of Olefins

Eiji Yamaguchi, Wakako Tanaka and Akichika Itoh

Chemistry An Asian Journal, 2019, 14, 121
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Precatalyst Effects on Pd-Catalyzed Cross-Coupling Difluoromethylation of Aryl Boronic Acids

Kaishi Hori, Hirotaka Motohashi, Daichi Saito and Koichi Mikami

ACS Catal., 2019, 9, 417
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Pd-Catalyzed Divergent Site-Selective Difluoromethylation and Difluoromethylcarbonylation of Aryl Sulfonium Salts

Xujuan Jiang, Wenbo Gong, Xiaoxun Li, Sitian Wang, Zongyi Gu, Yuhao Yang and Xiaojun Zeng

ACS Catal., 2024, 14, 13557
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Chiral copper-catalyzed enantioselective Michael difluoromethylation of arylidene meldrum's acids with (difluoromethyl)zinc reagents

Yu Endo, Koki Ishii and Koichi Mikami

Tetrahedron, 2019, 75, 4099
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Nickel‐Catalyzed Markovnikov‐Selective Hydrodifluoromethylation of Alkynes Using BrCF2H

Shiwei Pan, Fan Chen, Yanyan Zhang, Liang Shao and Lingling Chu

Angewandte Chemie, 2023, 135
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Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

Devin M. Ferguson, Christian A. Malapit, James R. Bour and Melanie S. Sanford

J. Org. Chem., 2019, 84, 3735
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Ligand-Less Iron-Catalyzed Aromatic Cross-Coupling Difluoromethylation of Grignard Reagents with Difluoroiodomethane

Hirotaka Motohashi, Miki Kato and Koichi Mikami

J. Org. Chem., 2019, 84, 6483
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[Ph4P]+[Cu(CF2H)2]−: A Powerful Difluoromethylating Reagent Inspired by Mechanistic Investigation

Haiwei Zhao, Xuebing B. Leng, Wei Zhang and Qilong Shen

Angewandte Chemie, 2022, 134
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Research Progress on Palladium-Catalyzed Difluoromethyl Arylation

钰沣陈

JOCR, 2025, 13, 21
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Electrochemical hydrodefluorination of an aromatic trifluoromethyl group with ammonia as the hydrogen source

Jie Sheng, Jiaming Cheng and Xu Cheng

Tetrahedron Chem, 2024, 10, 100074
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Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

Wenjun Miao, Yanchuan Zhao, Chuanfa Ni, Bing Gao, Wei Zhang and Jinbo Hu

J. Am. Chem. Soc., 2018, 140, 880
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Nickel‐Catalyzed Markovnikov‐Selective Hydrodifluoromethylation of Alkynes Using BrCF2H

Shiwei Pan, Fan Chen, Yanyan Zhang, Liang Shao and Lingling Chu

Angew Chem Int Ed, 2023, 62
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Sulfonium Ylide Enabled, Copper-Catalyzed Difluoromethylation, Monofluoromethylation, and Monofluoroalkylation of Lithium Aryl nButyl Borates

Feng Gao, Yisa Xiao, Zimeng Li and Qilong Shen

ACS Catal., 2025, 15, 4644
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Terminal C(sp3) H alkylation of internal alkenes via Ni/H-catalyzed isomerization

Zhen-Yu Wang, Jia-Hao Wan, Gao-Yin Wang, Rui Wang, Ruo-Xing Jin, Quan Lan and Xi-Sheng Wang

Tetrahedron Letters, 2018, 59, 2302
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Palladium‐Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

Fei Pan, Gregory B. Boursalian and Tobias Ritter

Angew Chem Int Ed, 2018, 57, 16871
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Difluoromethylation of alcohols with TMSCF2Br in water: A new insight into the generation and reactions of difluorocarbene in a two-phase system

Rongyi Zhang, Chuanfa Ni, Qiqiang Xie and Jinbo Hu

Tetrahedron, 2020, 76, 131676
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Nickel‐Catalyzed Reductive Coupling for Transforming Unactivated Aryl Electrophiles into β‐Fluoroethylarenes

Yi Yang, Gen Luo, Youlin Li, Xia Tong, Mengmeng He, Hongyao Zeng, Yan Jiang, Yingle Liu and Yubin Zheng

Chemistry An Asian Journal, 2020, 15, 156
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Two Ligands Transfer from Ag to Pd: En Route to (SIPr)Pd(CF2H)(X) and Its Application in One-Pot C–H Borylation/Difluoromethylation

Haiwei Zhao, Simon Herbert, Tom Kinzel, Wei Zhang and Qilong Shen

J. Org. Chem., 2020, 85, 3596
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Introduction of Difluoromethyl Through Radical Pathways

Xin Li and Qiuling Song

Eur J Org Chem, 2024, 27
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Palladium‐catalyzed difluoromethylation and difluoroalkylation reactions: An overview

Padinjare Veetil Saranya, Thaipparambil Aneeja and Gopinathan Anilkumar

Applied Organom Chemis, 2022, 36
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Nickel‐Catalyzed Carbofluoroalkylation of 1,3‐Enynes to Access Structurally Diverse Fluoroalkylated Allenes

Kai‐Fan Zhang, Kang‐Jie Bian, Chao Li, Jie Sheng, Yan Li and Xi‐Sheng Wang

Angew Chem Int Ed, 2019, 58, 5069
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A Protocol for the Synthesis of CF2H-Containing Pyrazolo[1,5-c]quinazolines from 3-Ylideneoxindoles and in Situ Generated CF2HCHN2

Wen-Yong Han, Jian-Shu Wang, Jia Zhao, Lin Long, Bao-Dong Cui, Nan-Wei Wan and Yong-Zheng Chen

J. Org. Chem., 2018, 83, 6556
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Sulfone Electrophiles in Cross-Electrophile Coupling: Nickel-Catalyzed Difluoromethylation of Aryl Bromides

Benjamin K. Chi, Samantha J. Gavin, Benjamin N. Ahern, Nikita Peperni, Sebastien Monfette and Daniel J. Weix

ACS Catal., 2024, 14, 11087
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Nickel and Copper Catalyzed ipso‐Phosphonodifluoromethylation of Arylboronic Acids with BrCF2P(O)(OEt)2 for the Synthesis of Phosphonodifluoromethylarenes

Alexander Knieb, Vinayak Krishnamurti, Xanath Ispizua‐Rodriguez and G. K. Surya Prakash

Chemistry A European J, 2022, 28
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Photocatalyzed Cyanodifluoromethylation of Alkenes

Min Zhang, Jin‐Hong Lin and Ji‐Chang Xiao

Angew Chem Int Ed, 2019, 58, 6079
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Radical fluoroalkylation reactions involving fluorinated gases: Recent advancements and prospects

Chang-Cheng Wang and Bin Yang

Tetrahedron Letters, 2024, 141, 155038
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Highly Enantioselective Decarboxylative Difluoromethylation

Xian Zhao, Chao Wang, Lingfeng Yin and Wei Liu

J. Am. Chem. Soc., 2024, 146, 29297
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[Ph4P]+[Cu(CF2H)2]−: A Powerful Difluoromethylating Reagent Inspired by Mechanistic Investigation

Haiwei Zhao, Xuebing B. Leng, Wei Zhang and Qilong Shen

Angew Chem Int Ed, 2022, 61
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A Difluoromethylation Reagent: Access to Difluoromethyl Arenes through Palladium Catalysis

Xia Chen, Yining Liu, Sheng Zhang, Yang Li, Xiao-Yu Zhou, Xiaoqiang Yu, Xiujuan Feng, Yoshinori Yamamoto and Ming Bao

Org. Lett., 2024, 26, 6024
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