Synthesis, G-quadruplex binding properties and cytotoxicity of naphthalimide–thiourea conjugates

Zhize Ou, Moheng Xu, Yunyan Gao, Rui Hu, Qingqing Li, Wenjiao Cai, Ziji Wang, Yimeng Qian and Guoqiang Yang

New J. Chem., 2017, 41, 9397
DOI: 10.1039/C7NJ02366A

Fluorogenic Pt complexes distinguish the quantity and folding behavior of RNA G-quadruplexes between live cancerous and healthy cells

Lei He, Zhenyu Meng, Qianqian Guo, Xiangyang Wu, Marie-Paule Teulade-Fichou, Edwin Kok Lee Yeow and Fangwei Shao

Chem. Commun., 2020, 56, 14459
DOI: 10.1039/D0CC05622G

Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand

Zhize Ou, Yimeng Qian, Yunyan Gao, Yunqing Wang, Guoqiang Yang, Yi Li, Kaiyue Jiang and Xin Wang

RSC Adv., 2016, 6, 36923
DOI: 10.1039/C6RA01441K

Novel ruthenium(ii) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

Guoliang Liao, Xiang Chen, Jingheng Wu, Chen Qian, Hanqiang Wang, Liangnian Ji and Hui Chao

Dalton Trans., 2014, 43, 7811
DOI: 10.1039/c3dt53547a

Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA

Verity S. Stafford, Kogularamanan Suntharalingam, Arun Shivalingam, Andrew J. P. White, David J. Mann and Ramon Vilar

Dalton Trans., 2015, 44, 3686
DOI: 10.1039/C4DT02910K

Octahedral ruthenium complexes selectively stabilize G-quadruplexes

Lei He, Xiang Chen, Zhenyu Meng, Jintao Wang, Keyin Tian, Tianhu Li and Fangwei Shao

Chem. Commun., 2016, 52, 8095
DOI: 10.1039/C6CC03117J

G-quadruplex DNA selective targeting for anticancer therapy: a computational study of a novel PtII monofunctional complex activated by adaptive binding

Daniele Belletto, Fortuna Ponte, Nico Sanna, Stefano Scoditti and Emilia Sicilia

Dalton Trans., 2023, 52, 13517
DOI: 10.1039/D3DT02678G

Synthesis and antitumor mechanisms of two novel platinum(ii) complexes with 3-(2′-benzimidazolyl)-7-methoxycoumarin

Qi-Pin Qin, Shu-Long Wang, Ming-Xiong Tan, Zhen-Feng Wang, Xiao-Ling Huang, Qing-Min Wei, Bei-Bei Shi, Bi-Qun Zou and Hong Liang

Metallomics, 2018, 10, 1160
DOI: 10.1039/C8MT00125A

Synthesis, characterization and biological evaluation of six highly cytotoxic ruthenium(ii) complexes with 4′-substituted-2,2′:6′,2′′-terpyridine

Qi-Pin Qin, Ting Meng, Ming-Xiong Tan, Yan-Cheng Liu, Shu-Long Wang, Bi-Qun Zou and Hong Liang

Med. Chem. Commun., 2018, 9, 525
DOI: 10.1039/C7MD00532F

Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex

Lei He, Zhenyu Meng, Dechen Xu and Fangwei Shao

Sci Rep, 2018, 8
DOI: 10.1038/s41598-017-19095-y

Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics

Ritapa Chaudhuri, Semantee Bhattacharya, Jyotirmayee Dash and Santanu Bhattacharya

J. Med. Chem., 2021, 64, 42
DOI: 10.1021/acs.jmedchem.0c01145

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Lavinia A. Carabet, Paul S. Rennie and Artem Cherkasov

IJMS, 2018, 20, 120
DOI: 10.3390/ijms20010120

Relevance of G-quadruplex structures to pharmacogenetics

Simone L. Cree and Martin A. Kennedy

Front. Pharmacol., 2014, 5
DOI: 10.3389/fphar.2014.00160

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.

Caitlin E. Miron, Laura van Staalduinen, Alana M. Rangaswamy, Mickey Chen, Yushi Liang, Zongchao Jia, Jean‐Louis Mergny and Anne Petitjean

Angewandte Chemie, 2021, 133, 2530
DOI: 10.1002/ange.202012520

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.

Caitlin E. Miron, Laura van Staalduinen, Alana M. Rangaswamy, Mickey Chen, Yushi Liang, Zongchao Jia, Jean‐Louis Mergny and Anne Petitjean

Angew Chem Int Ed, 2021, 60, 2500
DOI: 10.1002/anie.202012520

Targeting human telomeric and c-myc G-quadruplexes with alkynylplatinum(II) terpyridine complexes under molecular crowding conditions

Zhize Ou, Yunqing Wang, Yunyan Gao, Xiaobing Wang, Yimeng Qian, Yi Li and Xuesong Wang

Journal of Inorganic Biochemistry, 2017, 166, 126
DOI: 10.1016/j.jinorgbio.2016.11.012

Stabilization of Human Telomeric G‐Quadruplex and Inhibition of Telomerase Activity by Propeller‐Shaped Trinuclear PtII Complexes

Cui‐Xia Xu, Yong Shen, Qian Hu, Yu‐Xuan Zheng, Qian Cao, Peter Z. Qin, Yong Zhao, Liang‐Nian Ji and Zong‐Wan Mao

Chemistry An Asian Journal, 2014, 9, 2519
DOI: 10.1002/asia.201402258

A redox-activated Pt(IV) pro-probe: From G-quadruplex imaging to cancer therapy

Qianqian Guo, Meijun Huang, Chaochen Wang and Fangwei Shao

Journal of Inorganic Biochemistry, 2022, 237, 111988
DOI: 10.1016/j.jinorgbio.2022.111988

Ru-indoloquinoline complex as a selective and effective human telomeric G-quadruplex binder

Hui-juan Yu, Ying Zhao, Wei-jie Mo, Zhi-feng Hao and Lin Yu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 132, 84
DOI: 10.1016/j.saa.2014.04.160

Preparation of 4-([2,2′:6′,2″-terpyridin]-4′-yl)-N,N-diethylaniline Ni II and Pt II complexes and exploration of their in vitro cytotoxic activities

Hua-Hong Zou, Li Wang, Zhi-Xiang Long, Qi-Pin Qin, Zhong-Kui Song, Tao Xie, Shu-Hua Zhang, Yan-Cheng Liu, Bin Lin and Zhen-Feng Chen

European Journal of Medicinal Chemistry, 2016, 108, 1
DOI: 10.1016/j.ejmech.2015.11.005

Phenanthroline-2,9-bistriazoles as selective G-quadruplex ligands

Mads Corvinius Nielsen, Anders Foller Larsen, Faisal Hussein Abdikadir and Trond Ulven

European Journal of Medicinal Chemistry, 2014, 72, 119
DOI: 10.1016/j.ejmech.2013.11.027

Aza-bridged bisphenanthrolinyl Pt(II) complexes: Efficient stabilization and topological selectivity on telomeric G-quadruplexes

Lei He, Zhenyu Meng, Yi-qun Xie, Xiang Chen, Tianhu Li and Fangwei Shao

Journal of Inorganic Biochemistry, 2017, 166, 135
DOI: 10.1016/j.jinorgbio.2016.11.011

Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity

Qi-Pin Qin, Jiao-Lan Qin, Ting Meng, Gui-Ai Yang, Zu-Zhuang Wei, Yan-Cheng Liu, Hong Liang and Zhen-Feng Chen

Sci Rep, 2016, 6
DOI: 10.1038/srep37644

The interactions of Pu22 G-quadruplex, derived from c-MYC promoter sequence, with antitumor acridine derivatives—An NMR/MD combined study

Tomasz Laskowski, Michał Kosno, Witold Andrałojć, Julia Pakuła, Rafał Stojałowski, Julia Borzyszkowska-Bukowska, Ewa Paluszkiewicz and Zofia Mazerska

Molecular Therapy Nucleic Acids, 2025, 36, 102513
DOI: 10.1016/j.omtn.2025.102513

Molecular Basis for Differential Recognition of G‐Quadruplex versus Double‐Helix DNA by Bis‐Phenanthroline Metal Complexes

Riccardo Rigo, Sara Bianco, Caterina Musetti, Manlio Palumbo and Claudia Sissi

ChemMedChem, 2016, 11, 1762
DOI: 10.1002/cmdc.201600129

Iridium Complexes as a Roadblock for DNA Polymerase during Amplification

Falguni Chandra, Prashant Kumar, Suman Kumar Tripathi, Srikanta Patra and Apurba L. Koner

ChemMedChem, 2016, 11, 1410
DOI: 10.1002/cmdc.201600101

5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions

Zu-Zhuang Wei, Qi-Pin Qin, Ting Meng, Cai-Xing Deng, Hong Liang and Zhen-Feng Chen

European Journal of Medicinal Chemistry, 2018, 145, 360
DOI: 10.1016/j.ejmech.2017.12.092

Targeting MYC: From understanding its biology to drug discovery

Julie Ross, Caitlin E. Miron, Jessica Plescia, Patricia Laplante, Kevin McBride, Nicolas Moitessier and Tarik Möröy

European Journal of Medicinal Chemistry, 2021, 213, 113137
DOI: 10.1016/j.ejmech.2020.113137

Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents

Iva Zonjić, Marijana Radić Stojković, Ivo Crnolatac, Ana Tomašić Paić, Silvia Pšeničnik, Aleksey Vasilev, Meglena Kandinska, Mihail Mondeshki, Stanislav Baluschev, Katharina Landfester, Ljubica Glavaš-Obrovac, Marijana Jukić, Juran Kralj, Anamaria Brozovic, Lucija Horvat and Lidija-Marija Tumir

Bioorganic Chemistry, 2022, 127, 105999
DOI: 10.1016/j.bioorg.2022.105999

Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine

Jiao-Lan Qin, Qi-Pin Qin, Zu-Zhuang Wei, Yan-Cheng Yu, Ting Meng, Chen-Xuan Wu, Yue-Lan Liang, Hong Liang and Zhen-Feng Chen

European Journal of Medicinal Chemistry, 2016, 124, 417
DOI: 10.1016/j.ejmech.2016.08.054

Exploration of head-to-tail and head-to-head isomers of a guanine quadruplex platinum-based binder

Jacob Joel Kirsh Carson, Caitlin Elizabeth Miron, Jingwei Luo, Jean-Louis Mergny, Laura van Staalduinen, Zongchao Jia and Anne Petitjean

Inorganica Chimica Acta, 2021, 518, 120236
DOI: 10.1016/j.ica.2020.120236

Synthesis, characterization, DNA binding, topoisomerase I inhibition, and antiproliferation activities of (di-tert-butylbipyridine) platinum(II) complexes

Keke Chai, Yihui Jiang, Tianzhi Han, Xuemin Duan and Jintao Wang

Transit Met Chem, 2018, 43, 657
DOI: 10.1007/s11243-018-0254-0

Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands

Agata Głuszyńska and Bernard Juskowiak

Molecules, 2019, 24, 965
DOI: 10.3390/molecules24050965

Synthesis and G-Quadruplex-binding Properties of Cationic Platinum(II) Terpyridine Complexes Containing σ-Alkynyl Auxiliaries

Zhize Ou, Zhao Feng, Guixia Liu, Yongjie Chen, Yunyan Gao, Yi Li and Xuesong Wang

Chemistry Letters, 2015, 44, 425
DOI: 10.1246/cl.141045

Nucleobase Stacking Sustained by Pt−Pt Interactions

Carmen Lorenzo‐Aparicio, Pablo García‐Álvarez, Javier A. Cabeza, Mar Gómez‐Gallego and Miguel A. Sierra

ChemistryEurope, 2024, 2
DOI: 10.1002/ceur.202300065

Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo

Qi-Pin Qin, Jiao-Lan Qin, Ming Chen, Yu-Lan Li, Ting Meng, Jie Zhou, Hong Liang and Zhen-Feng Chen

Oncotarget, 2017, 8, 61982
DOI: 10.18632/oncotarget.18778

Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Tumor Cell Apoptosis by Organoplatinum(II) Complexes with Oxoisoaporphine

Zhen-Feng Chen, Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li, Ting Meng, Guo-Hai Zhang, Yan Peng, Xu-Jian Luo and Hong Liang

J. Med. Chem., 2015, 58, 2159
DOI: 10.1021/jm5012484