In situ oxidizable directing group-enabled enantioselective synthesis of chiral platform ferrocene formaldehydes†
Devendra
Parganiha, 
a
Ashwini Dilip
Dhumale,
a
Yagya Dutt
Upadhyay,
a
Vishal
Choudhary,
a
Svastik
Jaiswal,
a
Raushan Kumar
Jha
a
and
Sangit
Kumar
*a
a
Ashwini Dilip
Dhumale,
a
Yagya Dutt
Upadhyay,
a
Vishal
Choudhary,
a
Svastik
Jaiswal,
a
Raushan Kumar
Jha
a
and
Sangit
Kumar
*a
Abstract
Herein, we have developed an efficient oxidatively removable directing group approach, enabling highly enantioselective PdII-catalyzed C–H activation. Successful rationalization of difficult C–H activation over the labile β-H oxidation step led to the direct synthesis of chiral 2-alkenylated ferrocene formaldehydes with up to 71% yields and 98 : 2 er.
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