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RSC Chemical Biology

Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan

Lloyd Declan Murphy,   Saeed Akkad,   Angelo Lopez,   Morgan Batiste-Simms,   Greg Laughlan McNeil,   Eva Wu-Di Wan,   Kathryn Huxley,   Luke Julyan,   Mia Shandell  and  Lianne Willems  

Abstract

The glycoprotein α-dystroglycan is essential in establishing cell-matrix interactions and is implicated in the pathology of muscular dystrophies. Novel tools are needed to study its rare and intriguing O-mannosyl glycans. This report describes the synthesis and evaluation of alkyne-tagged ribitol-5-phosphate derivatives for the metabolic labelling of α-dystroglycan in mammalian cells.

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DOI
https://doi.org/10.1039/D5CB00187K
Article type
Communication
Submitted
19 Jul 2025
Accepted
10 Oct 2025
First published
10 Oct 2025
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2025, Accepted Manuscript

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Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan

L. D. Murphy, S. Akkad, A. Lopez, M. Batiste-Simms, G. L. McNeil, E. W. Wan, K. Huxley, L. Julyan, M. Shandell and L. Willems, RSC Chem. Biol., 2025, Accepted Manuscript , DOI: 10.1039/D5CB00187K

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