Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Cátia Parente Carvalho; Amir Norouzy; Vera Ribeiro; Werner M. Nau; Uwe Pischel

doi:10.1039/C4OB02122C

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Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Cátia Parente Carvalho, Amir Norouzy, Vera Ribeiro, Werner M. Nau and Uwe Pischel
Org. Biomol. Chem., 2015,13, 2866-2869
DOI: 10.1039/C4OB02122C, Communication

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Abstract | Cited by

Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.

Graphical abstract: Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

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