Synthesis of imatinib using greener solvents: a sustainable approach

Abstract

A new, improved method for the synthesis of imatinib using environmentally friendly solvents is described. Key transformations such as aminocarbonylation and reduction were carried out in aqueous micellar media. In addition, all intermediates were isolated without any tedious workup or purification process, achieving an overall yield of approximately 45%. Compared with previously reported manufacturing processes that use hazardous organic solvents, the current process used substantially lesser organic solvents. Furthermore, the methodology was studied for the degree of ‘‘green metrics,’’ suggesting that the reaction conditions were environmentally benign.