G-quadruplexes (G4s) regulate multiple biological processes by interacting with G4-binding proteins (G4BPs). We developed a sandwich ELISA system to evaluate G4 ligand effects on G4-G4BP binding. G4 ligands strongly affect G-quartet-protein interactions, demonstrating that high binding affinity of G4 ligands for G4s does not guarantee ternary complex formation with G4BPs.
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Y. Tanaya, M. Sashida, H. Masai, H. Sasanuma, D. Miura, R. Asano, K. Nagasawa and M. Tera, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02801A
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