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Total synthesis of isatindigotindoline C, a 3,3′-spiropyrrolidine oxindole alkaloid, is achieved in two steps using an exo-selective decarboxylative 1,3-dipolar cycloaddition as the key step. The synthesis verifies the originally assigned relative anti-stereochemistry for the bis-oxindole core of isatindigotindoline C.

Graphical abstract: Total synthesis of isatindigotindoline C

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