Dattatraya H. Dethe and Raghavender Boda
Org. Biomol. Chem., 2016,14, 5843-5860
DOI:
10.1039/C6OB00861E,
Paper
Cu(OTf)2 catalyzed [6 + 2] cycloaddition reaction of indolyl-2-carbinols with various dienophiles such as indole derived α,β-unsaturated esters, ketones, nitriles and cinnamates is described. The strategy was further applied for the synthesis of optically active pyrrolo[1,2-a]indoles in >97% de using the chiral auxiliary based approach.
![Graphical abstract: Expedient synthesis of densely substituted pyrrolo[1,2-a]indoles](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6OB00861E "Graphical abstract")
