Editorial – in vivo analysis
This Editorial introduces Analyst's themed collection on In Vivo Analysis, guest edited by Lanqun Mao.
A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue
We review the work of “voltammetry next to a microdialysis probe” as measured by dopamine and the surrounding tissue.
Vesicular exocytosis and microdevices – microelectrode arrays
Among all the analytical techniques capable of monitoring exocytosis in real time at the single cell level, electrochemistry (particularly amperometry at a constant potential) using ultramicroelectrodes has been demonstrated to be an important and convenient tool for more than two decades.
Selected recent in vivo studies on chemical measurements in invertebrates
Review of in vivo analysis of brain chemicals in invertebrates.
Critical Review
A review of flux considerations for in vivo neurochemical measurements
The mass transport of neurochemicals in the brain and how this flux affects chemical measurements and data interpretation is reviewed.
Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging
Chemical tools that can report radioactive isotopes would be of interest to the defense community.
Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC–ECD
Chromatograms of 5-HT in 20 μl microdialysate of MVN in the USSCO group (solid line), in the control group (dotted line) before surgery (black), and postoperative days one (red), three (blue), and five (green).
In vivo histamine voltammetry in the mouse premammillary nucleus
A modified histamine selective waveform with fast scan cyclic voltametry provides a stimulation-locked and unique electrochemical signal towards histamine in vivo & in vitro.
Optical diagnosis of the progression and reversal of CCl4-induced liver injury in rodent model using minimally invasive autofluorescence spectroscopy
Schematic representation of the degree of intoxicant-induced liver injury and regeneration and the minimally invasive analysis using autofluorescence spectral features.
A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo
We present a new NIR fluorescent probe for the biosynthetic pathways of H2Sn in living cells and in vivo.
Development of an on-animal separation-based sensor for monitoring drug metabolism in freely roaming sheep
Lab-on-a-sheep: on-animal sensor using microdialysis coupled to microchip electrophoresis with electrochemical detection.
Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo
This study demonstrated the unaltered dopamine release in the striatum in a schizophrenia model dysbindin−/− mice.
Stabilization of Prussian blue with polyaniline and carbon nanotubes in neutral media for in vivo determination of glucose in rat brains
This study demonstrates a new electrochemical microbiosensor for selective in vivo monitoring of glucose in rat brains.
Electroanalysis of pM-levels of urokinase plasminogen activator in serum by phosphorothioated RNA aptamer
Electrochemical assay for the universal biomarker of several cancers, urokinase plasminogen activator, uPA, based on uPA-specific fluorinated RNA aptamer and methylene blue redox indicator, allows 1 pM uPA analysis in serum, making it practically useful for clinical applications.
Real-time monitoring of H2O2 release from single cells using nanoporous gold microelectrodes decorated with platinum nanoparticles
We present a self-supported nanoporous gold/PtNPs microelectrode with the sub-nanomolar sensitivity to detect H2O2 release from single cells.
Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson's disease
Changes in the striatal NMDA receptor-mediated control over striatofugal pathways in Parkinson's disease, as revealed by dual-probe microdialysis.
In vivo and continuous measurement of bisulfide in the hippocampus of rat's brain by an on-line integrated microdialysis/droplet-based microfluidic system
An on-line and continuous approach was demonstrated for in vivo measurement of bisulfide in rat's brain.
Mass spectrometric measurement of neuropeptide secretion in the crab, Cancer borealis, by in vivo microdialysis
Schematic representation of overall workflow for sampling secreted neuropeptides from the hemolymph by using a needle attached to a syringe or in vivo microdialysis.
A multi-enzyme microreactor-based online electrochemical system for selective and continuous monitoring of acetylcholine
This study demonstrates an online electrochemical system (OECS) for selective and continuous measurements of acetylcholine (ACh) through efficiently integrating in vivo microdialysis, a multi-enzyme microreactor and an electrochemical detector.
A microelectrochemical biosensor for real-time in vivo monitoring of brain extracellular choline
A first generation Pt-based polymer enzyme composite biosensor developed for real-time neurochemical monitoring was characterised in vivo for sensitive and selective detection of choline.
A durable non-enzymatic electrochemical sensor for monitoring H2O2 in rat brain microdialysates based on one-step fabrication of hydrogels
A non-enzymatic electrochemical H2O2 sensor was developed by in situ fabrication of biocompatible chitosan hydrogels, in which a specific recognition molecule for H2O2 – thionine – was stably immobilized via one-step electrodeposition.
About this collection
The issue is dedicated to the latest advances and developments in the area of in vivo analysis, including research articles and reviews in topics such as electrochemistry, fluorescence, photoacousic imaging and microdialysis. The issue was Guest Edited by Professor Lanqun Mao from the Institute of Chemistry, Chinese Academy of Sciences, read Professors Mao’s Editorial for an overview of this exciting area of research and the articles included in the issue.