Themed collection Celebrating 100 years of Chemistry at Nanjing University
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Self-assembled nanomaterials for biosensing and therapeutics: recent advances and challenges
Self-assembled nanomaterials (SANs) exhibit designable biofunctions owing to their tunable nanostructures and modifiable surfaces.
Analyst, 2021,146, 2807-2817
https://doi.org/10.1039/D1AN00077B
DNA origami: an outstanding platform for functions in nanophotonics and cancer therapy
The utilization of the DNA origami technique in the fabrication of complex objects has given rise to possibilities in DNA-induced precise manufacturing and might open a new era of bottom-up fabrication.
Analyst, 2021,146, 1807-1819
https://doi.org/10.1039/D0AN02160A
Gas-propelled biosensors for quantitative analysis
Gas-propelled biosensors display a simple gas-based signal amplification with quantitative detection features based on the target recognition event in combination with gas propulsion.
Analyst, 2021,146, 1115-1126
https://doi.org/10.1039/D0AN02154G
Progress in electrochemiluminescence of nanoclusters: how to improve the quantum yield of nanoclusters
Classification of nanoclusters and methods to improve their quantum yield and applications.
Analyst, 2021,146, 803-815
https://doi.org/10.1039/D0AN02110E
The electrochemical applications of rare earth-based nanomaterials
This review presents a general description of the synthesis and electrochemical properties of rare earth-based nanomaterials and their electrochemical applications.
Analyst, 2019,144, 6789-6811
https://doi.org/10.1039/C9AN01562K
Photoelectrochemical detection of metal ions
This review summarizes the fundamentals and recent progress in the photoelectrochemical detection of metal ions for the first time.
Analyst, 2016,141, 4262-4271
https://doi.org/10.1039/C6AN01123C
Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes
A simple target-responsive CRISPR/Cas12a-based strategy for translating molecular detection into a glucose test.
Analyst, 2021,146, 3114-3120
https://doi.org/10.1039/D1AN00008J
A ratiometric electrochemiluminescent cytosensor based on polyaniline hydrogel electrodes in spatially separated electrochemiluminescent systems
A three-channel ratiometric ECL platform for MCF-7 cells detection using potential-resolved ECL probes.
Analyst, 2021,146, 1835-1838
https://doi.org/10.1039/D0AN02408B
A simplified protein purification method through nickel cleavage of the recombinant protein from the Escherichia coli cell surface
A remarkable simple protein purification method is developed through nickel cleaving the target protein off the Escherichia coli cell surface.
Analyst, 2020,145, 6227-6231
https://doi.org/10.1039/D0AN01060J
An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid
An S-alkyl thiocarbamate bond in a caged fluorophore is selective to target hypochlorous acid but stable against Hg2+.
Analyst, 2018,143, 4251-4255
https://doi.org/10.1039/C8AN01027G
A near-infrared fluorescent aza-bodipy probe for dual-wavelength detection of hydrogen peroxide in living cells
A boronic acid functionalized aza-borondipyrromethene dye (azaBDPBA) was applied to the dual-wavelength detection of hydrogen peroxide with high selectivity, which was loaded into cells to indicate the alteration of intracellular hydrogen peroxide during biological processes.
Analyst, 2016,141, 2380-2383
https://doi.org/10.1039/C6AN00262E
Imaging of living cells and zebrafish in vivo using a ratiometric fluorescent probe for hydrogen sulfide
We have developed a novel colorimetric and ratiometric fluorescence probe for the selective and sensitive imaging of H2S in living cells and living zebrafish in vivo.
Analyst, 2015,140, 7165-7169
https://doi.org/10.1039/C5AN00119F
A nitrogen-doped graphene/gold nanoparticle/formate dehydrogenase bioanode for high power output membrane-less formic acid/O2 biofuel cells
A nitrogen-doped graphene/gold nanoparticle/formate dehydrogenase bioanode was proven to be effective in the catalytic oxidation of formic acid in biofuel cells.
Analyst, 2015,140, 1822-1826
https://doi.org/10.1039/C4AN02323D
Probing nucleus-enriched proteins in single living cells via a subcellular-resolved plasmonic immunosandwich assay
Specific extraction and ultrasensitive detection of low-copy-number nuclear proteins in single living cells were achieved via a subcellular-resolved plasmonic immunosandwich assay.
Analyst, 2021,146, 2878-2885
https://doi.org/10.1039/D1AN00003A
In vitro measurement of superoxide dismutase-like nanozyme activity: a comparative study
Analyzing the SOD-like activity of nanozymes in vitro is of great importance for identifying new nanozymes and predicting their potential biological effects in vivo.
Analyst, 2021,146, 1872-1879
https://doi.org/10.1039/D0AN02164D
Noninvasive ratiometric fluorescence imaging of γ-glutamyltransferase activity using an activatable probe
A ratiometric fluorescent probe constructed by covalently linking an ‘always-on’ BODIPY fluorophore with a GGT-activatable near-infrared (NIR) fluorescent substrate was reported for real-time imaging of GGT activity in living cells and in vivo.
Analyst, 2021,146, 1865-1871
https://doi.org/10.1039/D0AN02232B
A stepwise recognition strategy for the detection of telomerase activity via direct electrochemical analysis of metal–organic frameworks
A stepwise recognition strategy was developed for highly specific detection of telomerase activity via direct electrochemical analysis of metal–organic frameworks.
Analyst, 2021,146, 1859-1864
https://doi.org/10.1039/D0AN02233K
The discovery of lactoferrin dual aptamers through surface plasmon resonance imaging combined with a bioinformation analysis
An analytical method for screening multi-site recognition aptamers in lactoferrin molecules has been developed based on Surface Plasmon Resonance imaging, combined with the cluster classification calculation and molecular docking simulation.
Analyst, 2020,145, 6298-6306
https://doi.org/10.1039/D0AN01513J
Amplified electrochemiluminescence signals promoted by the AIE-active moiety of D–A type polymer dots for biosensing
Donor-acceptor type conjugated polymers were synthesized to obtain amplified electrochemiluminescence signals promoted by AIE-active moieties.
Analyst, 2020,145, 233-239
https://doi.org/10.1039/C9AN01992H
A new colorimetric assay method for the detection of anti-hepatitis C virus antibody with high sensitivity
A sensitive colorimetric assay method has been proposed for the detection of antibody by specifically assembling tandemly repeated DNAzymes on its “Y”-shaped structure, which has been used to determine anti-HCV Ab in serum with high sensitivity.
Analyst, 2019,144, 6365-6370
https://doi.org/10.1039/C9AN01466G
Fluorescent visual quantitation of cell-secreted sialoglycoconjugates by chemoselective recognition and hybridization chain reaction
A fluorescent visual method is developed for the quantitation of cell-secreted sialoglycoconjugates by chemoselective recognition and hybridization chain reaction.
Analyst, 2019,144, 4545-4551
https://doi.org/10.1039/C9AN00572B
From aggregation-induced to solution emission: a new strategy for designing ratiometric fluorescent probes and its application for in vivo HClO detection
The fluorescence of aggregation-induced emission is converted into that from ICT-induced emission in the presence of HClO.
Analyst, 2019,144, 1696-1703
https://doi.org/10.1039/C8AN01950A
Molecular profiling of single axons and dendrites in living neurons using electrosyringe-assisted electrospray mass spectrometry
Electrosyringe-assisted electrospray mass spectrometry (MS) is established for the first time to achieve intracellular sampling from one axon or dendrite in living neurons for mass spectrometric analysis.
Analyst, 2019,144, 954-960
https://doi.org/10.1039/C8AN00483H
A rolling circle amplification-assisted DNA walker triggered by multiple DNAzyme cores for highly sensitive electrochemical biosensing
A DNA walker triggered by multiple DNAzyme cores was constructed with the assistance of rolling circle amplification for electrochemical biosensing.
Analyst, 2019,144, 691-697
https://doi.org/10.1039/C8AN01892H
RNA chaperone assisted intramolecular annealing reaction towards oligouridylated RNA detection in cancer cells
An RNA chaperone assisted intramolecular annealing reaction for sensitive detection of genetic material in cell lysis and single cells was constructed.
Analyst, 2019,144, 186-190
https://doi.org/10.1039/C8AN01662C
Ultrasmall black phosphorus quantum dots: synthesis, characterization, and application in cancer treatment
We synthesized black phosphorus quantum dots with good fluorescence performance and excellent biocompatibility, and highlighted their great potential in the photothermal therapy of cancer.
Analyst, 2018,143, 5822-5833
https://doi.org/10.1039/C8AN01612G
A reaction-based near-infrared fluorescent probe that can visualize endogenous selenocysteine in vivo in tumor-bearing mice
Endogenously generated selenocysteine in tumor-bearing mice were selectively detected by our reaction-based NIR probe for the first time.
Analyst, 2018,143, 4860-4869
https://doi.org/10.1039/C8AN00765A
A novel porphyrin-based near-infrared fluorescent probe for hypochlorite detection and its application in vitro and in vivo
A porphyrin-based highly selective sensor for hypochlorite was applied in real-time detection of exogenous and endogenous ClO− in biological systems.
Analyst, 2018,143, 2641-2647
https://doi.org/10.1039/C8AN00586A
The amplified electrochemiluminescence response signal promoted by the Ir(III)-containing polymer complex
A novel Ir(III)-containing polymer complex can emit an apparently enhanced ECL signal using TPrA as a co-reactant in CH3CN solution due to the effective intramolecular metal–ligand charge transfer (MLCT) from the Ir(III)-complex centre to the polymer backbone.
Analyst, 2018,143, 2405-2410
https://doi.org/10.1039/C8AN00426A
A pH responsive AIE probe for enzyme assays
By combining leucine (Leu) and tetraphenylethene (TPE), a pH-sensitive aggregation induced emission (AIE) probe TPE-Leu was developed.
Analyst, 2018,143, 741-746
https://doi.org/10.1039/C7AN01710C
Target-induced cyclic DNAzyme formation for colorimetric and chemiluminescence imaging assay of protein biomarkers
A target-induced cyclic strategy for DNAzyme formation was developed for simple and sensitive colorimetric and chemiluminescence detection of protein biomarkers.
Analyst, 2017,142, 3740-3746
https://doi.org/10.1039/C7AN00413C
Signal amplification of microRNAs with modified strand displacement-based cycling probe technology
Micro ribose nucleic acids (miRNAs) play an important role in biological processes such as cell differentiation, proliferation and apoptosis.
Analyst, 2016,141, 6297-6302
https://doi.org/10.1039/C6AN01024E
Preparation of an aptamer based organic–inorganic hybrid monolithic column with gold nanoparticles as an intermediary for the enrichment of proteins
Gold nanoparticles are used as an intermediary in a sandwich structure for the preparation of an aptamer-based organic–inorganic hybrid affinity monolithic column.
Analyst, 2016,141, 4961-4967
https://doi.org/10.1039/C6AN00957C
Squaramide-based tripodal ionophores for potentiometric sulfate-selective sensors with high selectivity
A class of squaramide-based tripodal molecules was employed as new ionophores for highly sensitive and selective sulfate-selective sensors.
Analyst, 2015,140, 5317-5323
https://doi.org/10.1039/C5AN00259A
A Ti4+-immobilized phosphate polymer-patterned silicon substrate for on-plate selective enrichment and self-desalting of phosphopeptides
A circular hydrophobic–hydrophilic-Ti4+ immobilized phosphate polymer is patterned as the sample support for selective enrichment, wash-free self-desalting and mass spectroscopy (MS) analysis of phosphopeptides.
Analyst, 2015,140, 3216-3224
https://doi.org/10.1039/C5AN00102A
A rapid and convenient method for detecting a broad spectrum of malignant cells from malignant pleuroperitoneal effusion of patients using a multifunctional NIR heptamethine dye
We present a fluorescence-based method to detect malignant cells in clinical pleuroperitoneal effusion samples using a NIR heptamethine dye.
Analyst, 2015,140, 750-755
https://doi.org/10.1039/C4AN01958J
About this collection
2020 marks the 100th anniversary of chemistry at Nanjing University. This growing Editor’s choice collection celebrates this landmark anniversary by highlighting work published in Analyst from authors based at Nanjing University.