Electrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.
This review aims to provide an overview of the biosyntheses of the striking azetidine-containing natural products, with an emphasis on the biosynthetic mechanisms of naturally occurring azetidines.
This highlight provides an account of the discovery and advances in the tyrosine-click (Y-click) reaction and its extensive application in the mapping of proteins, imaging of living cells, and in the fields of analytical and medicinal chemistry.
Flavan-3-ols are important dietary bioactives. While fruits are significant sources of these compounds, fruit smoothies, particularly those with high levels of polyphenol oxidase, do not represent a viable option to increase flavan-3-ol intake.
A novel metal- and base-free controllable tandem cyclization/rearrangement strategy for divergent synthesis of CF3-containing 1-(aminomethyl)naphthalen-2-ols and 1-(2-naphthyl)azetidines is established.