The chirality introduced at the C1 position of 1-substituted-1,2,3,4-tetrahydroisoquinolines, obtained by four methods of enantioselective reduction of 1-substituted-3,4-dihydroisoquinolines, are vital for various biological activities.
The distinctive structural features and broad synthetic utility of carbohydrates have established them as key scaffolds in asymmetric synthesis.
Feature article on catalytic enantioselective reactions of ketimine-type α-iminoesters with the aim of accessing unnatural α-tertiary amino acids (ATAAs), which are highly valuable chemical molecules for natural products and functional materials.
This feature article highlights simplified recent protocols for the synthesis of borane–ammonia and borane–amines. The broad scope of borane–amine reactivity is discussed including recent applications in well-known and novel reactivity modes.
This review provides an overview of the important progress in FLP-catalyzed asymmetric reactions made over the past 15 years, and both the merits and limitations of FLP-catalysis have been highlighted.