Herein, we present a two-step approach for synthesizing 2,3-benzodiazepines from substituted indenes.
A novel synthesis of benzodiazepine-containing polyheterocyclics bearing a synthetically valuable vinyl substituent via C–H bond activation-initiated formal [5 + 2] annulation of 2-(indolin-1-yl)-1H-benzo[d]imidazoles with vinyl-1,3-dioxolan-2-one.
We designed a robust protocol to access p-quinone fused 5-substituted-1,4-benzodiazepine scaffolds, a new molecular hybrid, through InCl3 mediated Pictet–Spengler type cycloannulation of 2-amino-3-arylamino-p-quinone and aldehydes.
Solvent-tunable Rh(III)-catalysed C–H activation/[5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate was realized for building monofluorinated and gem-difluorinated benzodiazepines.
In this study, a new nanocomposite consisting of Ni2B nanoparticles anchored on magnetic functionalized multi-walled carbon nanotubes (Fe3O4/f-MWCNT/Ni2B) was synthesized and successfully used for the preparation of bioactive 1,4-benzodiazepines.