A synthesis of 1β-hydroxytestosterone, a metabolite of xenobiotic human cytochrome P450 enzymes, beginning with a borylation of boldione

Abstract

An 8-step synthesis of 1β-hydroxytestosterone was accomplished beginning with a conjugate borylation reaction of boldione.

Rationally engineering an H₂O₂-dependent P450 dihydroxylase for steroid functionalisation

Abstract

P450-catalysed steroid hydroxylation serves as both a fundamental biochemical pathway for in vivo steroid hormone biosynthesis and metabolism, and a pivotal tool for the biotechnological production of steroidal pharmaceuticals.

Correction: Voltammetric pH sensor based on electrochemically modified pseudo-graphite

Characterizing catalyst function and transformations in the plasma reduction of CO₂ on atomic layer deposition-synthesized catalysts

Abstract

Catalysts prepared by atomic layer deposition allow for comparisons between structurally-identical metal oxide catalysts for CO₂ reduction in non-thermal plasmas.

Automated instant labeling chemistry workflow for real-time monitoring of monoclonal antibody N-glycosylation

Abstract

Integration of Instant Procainamide (Instant-PC) flow chemistry into the N-GLYcanyzer PAT sequential injection system enables automated real-time monitoring of mAb N-glycosylation dynamics to facilitate advanced biologics manufacturing processes.