The electronic structure distribution of the newly synthesized anticancer agents.
Two novel series of pyridazin-3-ones, designed as potential vasodilators, demonstrated superior aortic vasorelaxant activity, eNOS mRNA expression and nitric oxide up-levelling.
The natural product myricetrin was obtained, structurally modified to introduce pyridazinone active small molecules, and studied for antiviral activity.
A novel synthesis of pyridazino[6,1-a]isoquinolin-5-ium-3-olate derivatives is described using a Rh(III)/AgSbF6 catalytic system. This is the first report on ortho-C–H bond annulation of 6-arylpyridazin-3(2H)-ones with disubstituted alkynes.
A concise Ru/Cu-catalyzed cascade providing rapid access to pyridazinoquinolinones and late-stage N-functionalization is reported.