Diverse syntheses of guaianolides are reviewed encompassing various strategies that display the tactics involved in addressing the key 5,7,5-core structure and various oxygenations ornamented in these molecules.
Sesquiterpene lactones (SLs) are a structurally diverse group of secondary metabolites primarily produced by plants, particularly within the Asteraceae family.
The asymmetric synthesis of highly functional 11-epi-badkhysin has been accomplished using a structure-unit based approach.
Juggling between reactivity and selectivity, free radical oxidation offers a unique means to synthesize natural products in a direct and efficient way. The case study of sesquiterpenes is illustrative of how modern total synthesis should be conducted.
This review highlights structural diversity, biosynthesis, biomimetic synthesis, and biological functions of trimeric natural products. These biosynthetic pathways could lead to the discovery of more bioactive trimers through (bio)synthesis.