A base-promoted [4 + 3] annulation of pyrrole-2-carbaldehydes with indene-2-carbaldehydes has been developed for synthesizing indene-fused pyrrolo[1,2-a]azepines.
An FeCl3-catalyzed AB2 three-component reaction of indole-2-carbaldehydes and 5-aminopyrazoles was established for the synthesis of indolo[3,2-b]carbazoles.
The allylic alkylation of indene-2-carbaldehydes with Morita–Baylis–Hillman (MBH) carbonates via pentaenolate activation is described. High stereoselectivities of the process rely on the use of a chiral tertiary amine as a nucleophilic catalyst.
Chiral N,N′-diaryl vicinal diamines have been synthesized enantioselectively via Cp*Rh-catalyzed tandem reductive amination/asymmetric transfer hydrogenation of quinoxaline-2-carbaldehydes with anilines using HCO2H/NEt3 (5/2) as the hydrogen source.
Herein, we describe an efficient strategy for an asymmetric one-pot methodology for the synthesis of N-phenyl thioether-tethered tetrasubstituted chiral 4,5-dihydropyrrole-3-carbaldehydes utilizing chiral amine as a organocatalysts.