This review highlights recent advances in maleimide-based annulation and cyclization strategies, offering insights into their synthetic versatility and potential applications in creating structurally diverse aromatics and bioactive heterocycles.
Substrates containing a β-chiral center provided good yields and high diastereoselectivity for cycloadducts forming 5- and 6-membered rings.
A systematic review of three major types of [5 + 2] cycloaddition reactions in natural product synthesis (2013–2024), highlighting their power in constructing complex frameworks through direct comparisons with alternative synthetic strategies.
Herein, we describe nickel-catalyzed nitrile hydroboration with pinacolborane, wherein a tethered NHC–pyridonate ligand enables cooperative activation of both reagents simultaneously to achieve efficient catalysis at room temperature.
This review article portrays the versatility of vinyl cyclopropanes and their heteroatom analogues and highlights their capacity to accomplish an array of highly stereoselective heterocyclic scaffolds via diverse reaction pathways.