FeBr3-catalysed synthesis of either 3-aroylimidazo[1,2-a]pyridines or 3,3′-(arylmethylene)bis(2-phenylimidazo[1,2-a]pyridines) derivatives from the same starting materials such as 2-arylimidazo[1,2-a]pyridines and aromatic aldehydes were reported.
We developed a CBr4-mediated, sustainable, solvent-free method to synthesize 2-arylimidazo[1,2-a]pyridines from 2-aminopyridines and acetophenones, enabling one-pot, oxidant-free C3 amino-functionalization and C3 bromo-functionalization using K2S2O8.
This feature article summarises our recent contributions to green-inspired designing and developing synthetic strategies for accessing several diversely functionalised biologically relevant organic scaffolds.
Herein we disclose the synthesis and an overview of all the functionalization reactions at each carbon atom, viz, C2, C3, C5, C6, C7 and C8 of imidazo[1,2-a]pyridine.
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.