This review will be an essential toolbox for medicinal and bioorganic chemists seeking novel multifunctional hybrid and bioactive N-heterocycles for drug discovery. The work highlights the need for and relevance of unexplored bioisosterism employing isoquinoline-based small-molecules in drug design.
This review highlights the synthesis of pharmaceutically important indolo/benzimidazo-isoquinoline derivatives via photo-, and electro-mediated functionalization/cyclization reactions of N-methacryloyl 2-aryl indoles/benzimidazoles.
A comparative study reveals condition-dependent selectivity in synthesizing benzimidazole-based thiazoles via conventional, solvent-free, and visible-light strategies.
An efficient Ru(II)-photoredox-catalyzed radical cascade between N-substituted 2-arylbenzoimidazoles and diaryliodonium triflates furnishing a variety of arylated-benzimidazo[2,1-a]isoquinolin-6(5H)-ones is achieved.
A convenient visible-light-promoted difluoromethylation/cyclization reaction to access various difluoromethylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones was developed using [Ph3PCF2H]+Br− as a difluoromethylated reagent.