Kaempferol binds to Keap1, leading to the release of Nrf2 and activation of the Nrf2 pathway, which enhance antioxidant and anti-inflammatory effects, inhibit hepatocyte ferroptosis, and alleviate APAP-induced liver injury.
Though hepatotoxicity induced by the ubiquitous and potentially ingested nanoplastics (NPs) has been extensively studied, limited attention has been given to the role of NPs' surface topography.
This study predicted the effect of strawberry anthocyanins on lipid metabolism through network pharmacology. The UPRmt mediated by ubl-5 plays a crucial role in beneficial effects of the Pg3G monomer on nematodes under oleic acid exposure.
The effective imaging of endogenous HNO is crucial for pathology research in biological systems. Here, a novel ratiometric photoacoustic probe in response to HNO was rationally developed to effectively assess HNO prodrug release and liver injury.
A turn-on pH fluorescent probe with a suitable pKa value of 6.73 has been designed and investigated. The probe can be applied to visualize lysosomal pH changes in living cells under stimulation by chloroquine and heat stroke, respectively.