This review covers the recent developments of synthetic routes of derivatization and anticancer activities of halogenated spirooxindoles scaffolds during 2020–2025, highlighting the molecular targets.
In this article, the stereoselective construction of spirooxindoles featuring larger ring size heterocycles are disclosed.
Cancer remains a major global health challenge and a leading cause of mortality. This ongoing burden underscores the need for continuous exploration of novel therapeutic strategies, prompting extensive review of emerging targets, mechanisms, and treatment approaches.
Recent updates on the synthesis of CF3-containing spirocyclic-oxindoles by employing N-2,2,2-trifluoroethylisatin ketimines are described in this review article.
This research elucidates how spirooxindoles inhibit CDK2 by employing structure-based methodologies, including molecular docking, MD simulations, and assessment of binding free energies.