This review covers the recent developments of synthetic routes of derivatization and anticancer activities of halogenated spirooxindoles scaffolds during 2020–2025, highlighting the molecular targets.
In this article, the stereoselective construction of spirooxindoles featuring larger ring size heterocycles are disclosed.
Cancer remains a major global health challenge and a leading cause of mortality. This ongoing burden underscores the need for continuous exploration of novel therapeutic strategies, prompting extensive review of emerging targets, mechanisms, and treatment approaches.
Recent updates on the synthesis of CF3-containing spirocyclic-oxindoles by employing N-2,2,2-trifluoroethylisatin ketimines are described in this review article.
The current review article focuses on azomethine ylide as a key component for the strategic synthesis of pyrrolidine and spiropyrrolidine derivatives, which are important structural motifs in many natural and synthetic bioactive molecules.