Herein, a chelation-assisted palladium-catalyzed ortho-acyloxylation of 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones is reported, enabling further elaboration toward the synthesis of benzofuran-fused pyridopyrimidinones.
A ruthenium(II)-catalyzed oxidative (4+3) C–H/C–H annulation of 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones with allyl alcohol to construct benzo[6,7]cyclohepta[1,2-d]pyrido[1,2-a]pyrimidin-8(5H)-ones has been developed.
Pyrimidine C–H activation can be efficiently achieved through three complementary strategies: metal-catalyzed, metal-free, and photochemical approaches enabling direct functionalization and structural diversification of heteroaromatic frameworks.
This review article highlights the sustainable developments of the visible light-induced heteroaryl – (hetero)aryl bond-forming reactions and their applications in synthesising various biologically active compounds, including drug molecules.
Three-component one-pot synthesis of benzothiazolopyrimidine derivatives through a CuAAC/ring cleavage/cyclization process.